Human Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) ELISA Kit | MyBioSource MBS9304470 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) ELISA Kit

catalog :

MBS9304470

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9304470

products type :

ELISA Kit

products full name :

Human Mitogen Activated Protein Kinase Kinase 6 (MAP2K6) ELISA Kit

products short name :

[Mitogen Activated Protein Kinase Kinase 6 (MAP2K6)]

other names :

[Map2k6 protein; Dual specificity mitogen-activated protein kinase kinase 6; dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MAP kinase kinase 6; mitogen-activated protein kinase kinase 3; mitogen-activated protein kinase kinase 6; Mitogen-activated protein kinase kinase 3]

products gene name :

[MAP2K6]

other gene names :

[map2k6; map2k6; MKK3; zMKK3; map2k3; map2k3; MAP kinase kinase 6; MAPKK 6; zMKK3]

uniprot entry name :

MP2K6_DANRE

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: The sensitivity of this kit is 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MAP2K6 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

182889926

ncbi acc num :

AAI65822.1

uniprot acc num :

Q9DGE0

ncbi mol weight :

40,594 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (822987); FGF Signaling Pathway (198948); GnRH Signaling Pathway (119274); GnRH Signaling Pathway (502); Immune System Pathway (822931); Innate Immune System Pathway (822957); Integrin-mediated Cell Adhesion Pathway (198949); MAP Kinase Activation In TLR Cascade Pathway (822965); MAPK Signaling Pathway (198945); MAPK Signaling Pathway (83627)

uniprot summary :

Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Phosphorylation by MAP2K6 asymmetrically activates p38 on one side of the blastodisc, an event which is necessary for blastomere cleavage. Ref.1. Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Enzyme regulation: Activated by dual phosphorylation on Ser-234 and Thr-238 in response to a variety of cellular stresses, including UV radiation, osmotic shock, hypoxia, inflammatory cytokines, interferon gamma (IFNG), and less often by growth factors. MAP2K6/MKK6 is activated by the majority of M3Ks . By similarity. Subunit structure: Dimer . By similarity. Interacts (via its D domain) with its MAP kinase substrates . By similarity. Interacts (via its DVD domain) with MAP3Ks activators . By similarity. Subcellular location: Nucleus . By similarity. Cytoplasm . By similarity. Cytoplasm cytoskeleton . By similarity. Note: Binds to microtubules . By similarity. Developmental stage: Expressed both maternally and zygotically. Zygotic expression continues throughout development. Ref.1. Domain: The DVD domain (residues 338-361) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation . By similarity.The D domain (residues 30-46) contains a conserved docking site and is required for the binding to MAPK substrates . By similarity. Post-translational modification: Weakly autophosphorylated . By similarity. Phosphorylated at Ser-234 and Thr-238 by the majority of M3Ks. Sequence similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.Contains 1 protein kinase domain. Caution: Was originally (Ref.1) thought to be a Map2k3 protein but sequence analysis shows closer similarity to the Map2k6 proteins. Sequence caution: The sequence AAH71285.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage