Human Frizzled Homolog 7 (FZD7) ELISA Kit | MyBioSource MBS9302973 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Frizzled Homolog 7 (FZD7) ELISA Kit

catalog :

MBS9302973

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9302973

products type :

ELISA Kit

products full name :

Human Frizzled Homolog 7 (FZD7) ELISA Kit

products short name :

Frizzled Homolog 7 (FZD7)

other names :

frizzled-7; Frizzled-7; frizzled-7; fz-7; hFz7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; FzE3

products gene name :

FZD7

other gene names :

FZD7; FZD7; FzE3; Fz-7; hFz7

uniprot entry name :

FZD7_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of FZD7 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

4503833

ncbi acc num :

NP_003498.1

ncbi gb acc num :

NM_003507.1

uniprot acc num :

O75084

ncbi mol weight :

63,620 Da

ncbi pathways :

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Class B/2 (Secretin Family Receptors) Pathway (106378); GPCR Ligand Binding Pathway (161020); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Melanogenesis Pathway (83092); Melanogenesis Pathway (504)

ncbi summary :

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

uniprot summary :

FZD7: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, Fz/Smo family. Chromosomal Location of Human Ortholog: 2q33. Cellular Component: plasma membrane; integral to membrane. Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; frizzled binding; PDZ domain binding. Biological Process: neuron differentiation; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation involved in wound healing; positive regulation of transcription, DNA-dependent; stem cell maintenance; T cell differentiation in the thymus; somatic stem cell division; positive regulation of JNK cascade; Wnt receptor signaling pathway through beta-catenin; satellite cell compartment self-renewal involved in skeletal muscle regeneration; negative regulation of ectodermal cell fate specification; positive regulation of phosphorylation

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage