Human Neurogenic Differentiation 1 (NEUROD1) ELISA Kit | MyBioSource MBS9302689 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Neurogenic Differentiation 1 (NEUROD1) ELISA Kit

catalog :

MBS9302689

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9302689

products type :

ELISA Kit

products full name :

Human Neurogenic Differentiation 1 (NEUROD1) ELISA Kit

products short name :

[Neurogenic Differentiation 1 (NEUROD1)]

other names :

[neurogenic differentiation factor 1; Neurogenic differentiation factor 1; neurogenic differentiation factor 1; beta-cell E-box transactivator 2; class A basic helix-loop-helix protein 3; neurogenic helix-loop-helix protein NEUROD; basic helix-loop-helix transcription factor; neuronal differentiation 1; Class A basic helix-loop-helix protein 3]

products gene name :

[NEUROD1]

other gene names :

[NEUROD1; NEUROD1; BETA2; BHF-1; MODY6; NEUROD; bHLHa3; BHLHA3; NEUROD; NeuroD; NeuroD1; bHLHa3]

uniprot entry name :

NDF1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Human Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25ng/ml-8ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of NEU3 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

ncbi gi num :

121114306

ncbi acc num :

NP_002491.2

ncbi gb acc num :

NM_002500.4

uniprot acc num :

Q13562

ncbi mol weight :

39,920 Da

ncbi pathways :

Developmental Biology Pathway (477129); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Regulation Of Beta-cell Development Pathway (106328); Regulation Of Gene Expression In Beta Cells Pathway (106332); Regulation Of Gene Expression In Endocrine-committed (NEUROG3+) Progenitor Cells Pathway (106331); SIDS Susceptibility Pathways (198901)

ncbi summary :

This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]

uniprot summary :

NEUROD1: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5 -CANNTG-3 . Associates with the p300/CBP transcription coactivator complex to stimulates transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor p21Cip1. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. Interacts (via helix-loop-helix motif domain) with EP300 (via C-terminus). Heterodimer with TCF3/E47; the heterodimer is inhibited in presence of ID2, but not NR0B2, to E- box element. Efficient DNA-binding requires dimerization with another bHLH protein. Interacts with RREB1. Interacts with EP300; the interaction is inhibited by NR0B2. Interacts with TCF3; the interaction is inhibited by ID2. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 2q32. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: protein binding; sequence-specific DNA binding; protein heterodimerization activity; double-stranded DNA binding; transcription coactivator activity; chromatin binding; transcription factor binding; transcription factor activity. Biological Process: response to drug; dentate gyrus development; transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; nucleocytoplasmic transport; glucose homeostasis; endocrine pancreas development; anterior/posterior pattern formation; embryonic organ morphogenesis; neurogenesis; insulin secretion; response to glucose stimulus; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of cell differentiation; positive regulation of neuron differentiation; negative regulation of JAK-STAT cascade; regulation of insulin secretion; nitric oxide mediated signal transduction; inner ear development. Disease: Maturity-onset Diabetes Of The Young, Type 6; Diabetes Mellitus, Noninsulin-dependent

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095