catalog number :
MBS9302325
products type :
ELISA Kit
products full name :
Human Sorting Nexin 2 (SNX2) ELISA Kit
products short name :
Sorting Nexin 2 (SNX2)
other names :
sorting nexin 2; Sorting nexin-2; sorting nexin-2; transformation-related gene 9 protein; sorting nexin 2; Transformation-related gene 9 protein
products gene name :
SNX2
other gene names :
SNX2; SNX2; TRG-9; TRG-9
uniprot entry name :
SNX2_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
AAB99852.1
ncbi mol weight :
58,471 Da
ncbi pathways :
Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Membrane Trafficking Pathway (106160); TGF-beta Receptor Signaling Pathway (198774); Trans-Golgi Network Vesicle Budding Pathway (106165)
ncbi summary :
This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]
uniprot summary :
SNX2: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family. Protein type: Vesicle. Chromosomal Location of Human Ortholog: 5q23. Cellular Component: extrinsic to membrane; protein complex; membrane; intracellular membrane-bound organelle; lamellipodium; retromer complex; early endosome membrane; cytoplasm; endosome membrane. Molecular Function: protein binding; phosphoinositide binding; insulin receptor binding; epidermal growth factor receptor binding. Biological Process: intracellular protein transport; vesicle organization and biogenesis; endocytosis; retrograde transport, endosome to Golgi; protein oligomerization