ELISA/assay

Human insulin-like growth factors binding protein 1, IGFBP-1 ELISA Kit

MBS9301956

96 Strip Wells

600 USD

ELISA Kit

Human insulin-like growth factors binding protein 1, IGFBP-1 ELISA Kit

insulin-like growth factors binding protein 1, IGFBP-1

insulin-like growth factor-binding protein 1; Insulin-like growth factor-binding protein 1; insulin-like growth factor-binding protein 1; IBP-1; IGFBP-1; binding protein-25; binding protein-26; binding protein-28; placental protein 12; IGF-binding protein 1; amniotic fluid binding protein; growth hormone independent-binding protein; alpha-pregnancy-associated endometrial globulin; insulin-like growth factor binding protein 1; Placental protein 12

IGFBP-1

IGFBP1; IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12

IBP1_HUMAN

Human

4504615

NP_000587.1

NM_000596.2

P08833

27,904 Da

Activation Of Genes By ATF4 Pathway 530772!!AhR Pathway 755436!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!HIF-1-alpha Transcription Factor Network Pathway 138045!!Metabolism Of Proteins Pathway 106230!!Myometrial Relaxation And Contraction Pathways 198759!!PERK Regulated Gene Expression Pathway 105907!!Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway 105908!!Unfolded Protein Response Pathway 105904

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Ref.20. Subunit structure: Binds equally well IGF1 and IGF2. Subcellular location: Secreted. Post-translational modification: Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis. Ref.14 Ref.18 Ref.20. Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain. Sequence caution: The sequence AAA52540.1 differs from that shown. Reason: Frameshift at positions 55 and 71.

96 Strip Wells

600 USD