ELISA/assay

Mouse Caspase-3/CPP32 ELISA Kit

MBS9300879

48-Strip-Wells

435 USD

ELISA Kit

Mouse Caspase-3/CPP32 ELISA Kit

Caspase-3/CPP32

CPP32; Caspase-3; caspase-3; SCA-1; CASP-3; CPP-32; protein Yama; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis related cysteine protease; caspase 3; Apopain; Cysteine protease CPP32; CPP-32; LICE; Protein Yama; SREBP cleavage activity 1

CPP32

Casp3; Casp3; CC3; AC-3; Lice; Yama; mldy; CPP32; Apopain; Caspase-3; A830040C14Rik; Cpp32; CASP-3; CPP-32; SCA-1

CASP3_MOUSE

Mouse

Store all reagents at 2-8 degree C

2114328

AAC53196.1

P70677

31,475 Da

Activation Of DNA Fragmentation Factor Pathway (819027); Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway (819017); Alpha6-Beta4 Integrin Signaling Pathway (198373); Alzheimer's Disease Pathway (83294); Alzheimer's Disease Pathway (509); Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Amyotrophic Lateral Sclerosis (ALS) Pathway (83296); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Androgen Receptor Signaling Pathway (198319)

CASP3: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp- -Gly-217 bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. Protein type: Motility/polarity/chemotaxis; Protease; EC 3.4.22.56; Apoptosis. Cellular Component: cytoplasm; nucleus; cytosol; lipid raft. Molecular Function: cyclin-dependent protein kinase inhibitor activity; peptidase activity; protein binding; phospholipase A2 activator activity; protease binding; hydrolase activity; cysteine-type endopeptidase activity; death receptor binding; protein complex binding; aspartic-type endopeptidase activity; cysteine-type peptidase activity. Biological Process: positive regulation of catalytic activity; apoptosis; positive regulation of apoptosis; negative regulation of activated T cell proliferation; heart development; negative regulation of B cell proliferation; proteolysis; negative regulation of cell cycle; neuron differentiation; sensory perception of sound; learning and/or memory; B cell homeostasis; positive regulation of neuron apoptosis; response to glucose stimulus; response to wounding; erythrocyte differentiation; T cell homeostasis; response to UV; release of cytochrome c from mitochondria; cell fate commitment; negative regulation of cyclin-dependent protein kinase activity; keratinocyte differentiation; neuron apoptosis; induction of apoptosis via death domain receptors; response to hydrogen peroxide; protein processing; induction of apoptosis by oxidative stress; response to DNA damage stimulus; negative regulation of apoptosis

48-Strip-Wells

435 USD

96-Strip-Wells

600