product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human mixed lineage kinase domain-like, MLKL ELISA Kit
catalog :
MBS9300811
quantity :
48-Strip-Wells
price :
435 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS9300811
products type :
ELISA Kit
products full name :
Human mixed lineage kinase domain-like, MLKL ELISA Kit
products short name :
mixed lineage kinase domain-like, MLKL
other names :
mixed lineage kinase domain-like protein isoform 2; Mixed lineage kinase domain-like protein; mixed lineage kinase domain-like protein; mixed lineage kinase domain-like
products gene name :
MLKL
other gene names :
MLKL; MLKL
uniprot entry name :
MLKL_HUMAN
reactivity :
Human
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich. Detection Range: 62.5 pg/ml - 2000 pg/ml. Sensitivity: 10 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MLKL (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi gi num :
215820622
ncbi acc num :
NP_001135969.1
ncbi gb acc num :
NM_001142497.1
uniprot acc num :
Q8NB16
ncbi mol weight :
54,479 Da
ncbi pathways :
DNA Damage Response (only ATM Dependent) Pathway (198827); TNF Signaling Pathway (812256); TNF Signaling Pathway (813210)
ncbi summary :
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
uniprot summary :
MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; TKL-Unique family. Chromosomal Location of Human Ortholog: 16q23.1. Cellular Component: cytoplasm; plasma membrane. Molecular Function: protein binding; protein complex binding; protein kinase binding; ATP binding; protein kinase activity. Biological Process: protein amino acid phosphorylation
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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