Human Triggering receptor expressed on myeloid cells 2, TREM2 ELISA Kit | MyBioSource MBS928570 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Triggering receptor expressed on myeloid cells 2, TREM2 ELISA Kit

catalog :

MBS928570

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS928570

products type :

ELISA Kit

products full name :

Human Triggering receptor expressed on myeloid cells 2, TREM2 ELISA Kit

products short name :

triggering receptor expressed on myeloid cells 2

products name syn :

Human Triggering receptor expressed on myeloid cells 2 (TREM2) ELISA kit; TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2

other names :

triggering receptor expressed on myeloid cells 2 isoform 2; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2

products gene name :

TREM2

other gene names :

TREM2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2

uniprot entry name :

TREM2_HUMAN

reactivity :

Human

sequence length :

230

specificity :

This assay has high sensitivity and excellent specificity for detection of human TREM2. No significant cross-reactivity or interference between human TREM2 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 0.312 ng/ml-20 ng/ml. Sensitivity: 0.078 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

products description :

Principle of the Assay This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TREM2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TREM2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TREM2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TREM2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

425876764

ncbi acc num :

NP_001258750.1

ncbi gb acc num :

NM_001271821.1

uniprot acc num :

Q9NZC2

ncbi mol weight :

25,447 Da

ncbi pathways :

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Other Semaphorin Interactions Pathway (119526); Semaphorin Interactions Pathway (119519)

ncbi summary :

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

uniprot summary :

TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: intracellular membrane-bound organelle; plasma membrane; extracellular region; integral to membrane. Molecular Function: peptidoglycan binding; lipopolysaccharide binding; receptor activity. Biological Process: axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; positive regulation of calcium-mediated signaling; humoral immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II. Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage