Human Myelin-oligodendrocyte glycoprotein, MOG ELISA Kit | MyBioSource MBS928110 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Myelin-oligodendrocyte glycoprotein, MOG ELISA Kit

catalog :

MBS928110

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS928110

products type :

ELISA Kit

products full name :

Human Myelin-oligodendrocyte glycoprotein, MOG ELISA Kit

products short name :

myelin oligodendrocyte glycoprotein

products name syn :

Human Myelin-oligodendrocyte glycoprotein (MOG) ELISA kit; DAQB-92E24.2; MGC26137; MOGIG2; MOG Ig-AluB; myelin oligodendrocyte glycoprotein

other names :

myelin-oligodendrocyte glycoprotein isoform alpha3; Myelin-oligodendrocyte glycoprotein; myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; MOG alpha-5; myelin oligodendrocyte glycoprotein

products gene name :

MOG

other gene names :

MOG; MOG; BTN6; BTNL11; MOGIG2; NRCLP7

uniprot entry name :

MOG_HUMAN

reactivity :

Human

sequence length :

224

specificity :

This assay has high sensitivity and excellent specificity for detection of Human MOG. No significant cross-reactivity or interference between Human MOG and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 15.6 pg/ml-1000 pg/ml. Sensitivity: 3.9 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for MOG has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any MOG present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MOG is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MOG bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

56788389

ncbi acc num :

NP_001008229.1

ncbi gb acc num :

NM_001008228.2

uniprot acc num :

Q16653

ncbi mol weight :

28,193 Da

ncbi summary :

The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 6p22.1. Cellular Component: plasma membrane; integral to membrane. Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion. Disease: Narcolepsy 7

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage