Human Beta-adrenergic receptor kinase 1, ADRBK1 ELISA Kit | MyBioSource MBS925953 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Beta-adrenergic receptor kinase 1, ADRBK1 ELISA Kit

catalog :

MBS925953

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS925953

products type :

ELISA Kit

products full name :

Human Beta-adrenergic receptor kinase 1, ADRBK1 ELISA Kit

products short name :

adrenergic, beta, receptor kinase 1

products name syn :

Human Beta-adrenergic receptor kinase 1 (ADRBK1) ELISA kit; BARK1; BETA-ARK1; FLJ16718; GRK2; beta-adrenergic receptor kinase 1; adrenergic; beta; receptor kinase 1

other names :

beta-adrenergic receptor kinase 1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1; beta-ARK-1; G-protein coupled receptor kinase 2; adrenergic, beta, receptor kinase 1; G-protein coupled receptor kinase 2

products gene name :

ADRBK1

other gene names :

ADRBK1; ADRBK1; GRK2; BARK1; BETA-ARK1; BARK; BARK1; GRK2; Beta-ARK-1

uniprot entry name :

ARBK1_HUMAN

reactivity :

Human

sequence length :

689

specificity :

This assay has high sensitivity and excellent specificity for detection of Human ADRBK1. No significant cross-reactivity or interference between Human ADRBK1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, Cell lysates. Detection Range: 18.75 pg/ml-1200 pg/ml. Sensitivity: 4.68 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

ncbi gi num :

148539876

ncbi acc num :

NP_001610.2

ncbi gb acc num :

NM_001619.3

uniprot acc num :

P25098

ncbi mol weight :

79,574 Da

ncbi pathways :

CXCR4-mediated Signaling Events Pathway (137910); Ca-dependent Events Pathway (106497); CaM Pathway (106468); Calmodulin Induced Events Pathway (106469); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); DAG And IP3 Signaling Pathway (477115); Disease Pathway (530764); Downstream Signal Transduction Pathway (106385); Downstream Signaling Of Activated FGFR Pathway (160957)

ncbi summary :

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

uniprot summary :

GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function. Protein type: Protein kinase, AGC; EC 2.7.11.15; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; GRK family; BARK subfamily. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: membrane; cytoplasm; plasma membrane; cytosol. Molecular Function: G-protein coupled receptor kinase activity; protein binding; Edg-2 lysophosphatidic acid receptor binding; beta-adrenergic receptor kinase activity; alpha-2A adrenergic receptor binding; ATP binding; protein kinase activity. Biological Process: epidermal growth factor receptor signaling pathway; tachykinin signaling pathway; desensitization of G-protein coupled receptor protein signaling pathway; acetylcholine receptor signaling, muscarinic pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; heart development; peptidyl-threonine phosphorylation; signal transduction; negative regulation of striated muscle contraction; peptidyl-serine phosphorylation; negative regulation of the force of heart contraction by chemical signal; phospholipase C activation; receptor internalization; innate immune response; positive regulation of catecholamine secretion; cardiac muscle contraction

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage