ELISA/assay

Human Complement component C8 alpha chain, C8A ELISA Kit

MBS924799

48-Strip-Wells

510 USD

ELISA Kit

Human Complement component C8 alpha chain, C8A ELISA Kit

complement component 8, alpha polypeptide

Human Complement component C8 alpha chain (C8A) ELISA kit; complement component 8; alpha polypeptide

complement component C8 alpha chain; Complement component C8 alpha chain; complement component C8 alpha chain; complement component 8 subunit alpha; complement component 8, alpha polypeptide; Complement component 8 subunit alpha

C8A

C8A; C8A

CO8A_HUMAN

Human

584

This assay has high sensitivity and excellent specificity for detection of Human C8A. No significant cross-reactivity or interference between Human C8A and analogues was observed.

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Samples: Serum, plasma, tissue homogenates. Detection Range: 1.56 ng/ml-100 ng/ml. Sensitivity: 0.39 ng/ml

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Complement. Protein Biological Process 3: Complement alternate pathway

4557389

NP_000553.1

NM_000562.2

P07357

65,163 Da

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Immune System Pathway (106386); Innate Immune System Pathway (106387); Prion Diseases Pathway (101144); Prion Diseases Pathway (100065)

C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]

C8A: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. Protein type: Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 1p32. Cellular Component: membrane attack complex; extracellular space; membrane; extracellular region. Molecular Function: complement binding; protein complex binding. Biological Process: cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; immune response; complement activation, classical pathway; complement activation. Disease: Complement Component 8 Deficiency, Type I

48-Strip-Wells

510 USD

96-Strip-Wells

725

5x96-Strip-Wells

2565

10x96-Strip-Wells

4800