Human Cytochrome P450 2B6, CYP2B6 ELISA Kit | MyBioSource MBS923467 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Cytochrome P450 2B6, CYP2B6 ELISA Kit

catalog :

MBS923467

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS923467

products type :

ELISA Kit

products full name :

Human Cytochrome P450 2B6, CYP2B6 ELISA Kit

products short name :

cytochrome P450, family 2, subfamily B, polypeptide 6

products name syn :

Human Cytochrome P450 2B6 (CYP2B6) ELISA kit; CPB6; CYP2B; CYPIIB6; IIB1; P450; cytochrome P450; subfamily IIB (phenobarbital-inducible); polypeptide 6; cytochrome P450; family 2; subfamily B; polypeptide 6

other names :

cytochrome P450 2B6; Cytochrome P450 2B6; cytochrome P450 2B6; cytochrome P450 IIB1; 1,4-cineole 2-exo-monooxygenase; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; cytochrome P450, family 2, subfamily B, polypeptide 6; 1,4-cineole 2-exo-monooxygenase; CYPIIB6; Cytochrome P450 IIB1

products gene name :

CYP2B6

other gene names :

CYP2B6; CYP2B6; CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6

uniprot entry name :

CP2B6_HUMAN

reactivity :

Human

sequence length :

491

specificity :

This assay has high sensitivity and excellent specificity for detection of Human CYP2B6. No significant cross-reactivity or interference between Human CYP2B6 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates, Cell lysates. Detection Range: 39 pg/ml-2500 pg/ml. Sensitivity: 9.75 pg/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul

ncbi gi num :

7949031

ncbi acc num :

NP_000758.1

ncbi gb acc num :

NM_000767.4

uniprot acc num :

P20813

ncbi mol weight :

56,278 Da

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (366); Biological Oxidations Pathway (105698); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Drug Metabolism - Cytochrome P450 Pathway (83032); Drug Metabolism - Cytochrome P450 Pathway (427); Metabolism Pathway (477135); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (83031); Metabolism Of Xenobiotics By Cytochrome P450 Pathway (425); Nicotine Metabolism Pathway (198914)

ncbi summary :

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

uniprot summary :

CYP2B6: cytochrome P450, subfamily IIB. Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Phosphorylation is accompanied by a decrease in enzyme activity. Protein type: EC 1.14.14.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - arachidonic acid; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm. Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity. Biological Process: steroid metabolic process; ketone metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway; drug metabolic process. Disease: Efavirenz, Poor Metabolism Of

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage