REG3G Antibody | MyBioSource MBS9230956 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

REG3G Antibody

catalog :

MBS9230956

quantity :

0.05 mL

price :

165 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[1790CT313.66.2]

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-REG3G Antibody at 1:1000 dilution + Human pancreas lysate. Lysates/proteins at 20 ug per lane. Secondary. Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 19 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

image 2 :

MBS9230956 staining REG3G in human pancreas tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.

product information

catalog number :

MBS9230956

products type :

Antibody

products full name :

REG3G Antibody

products short name :

[REG3G]

products name syn :

[Regenerating islet-derived protein 3-gamma; REG-3-gamma; Pancreatitis-associated protein 1B; PAP-1B; Pancreatitis-associated protein IB; PAP IB; Regenerating islet-derived protein III-gamma; REG III; Reg III-gamma; Regenerating islet-derived protein 3-gamma 16.5 kDa form; Regenerating islet-derived protein 3-gamma 15 kDa form; REG3G; PAP1B]

other names :

[regenerating islet-derived protein 3-gamma isoform 1 preproprotein; Regenerating islet-derived protein 3-gamma; regenerating islet-derived protein 3-gamma; regenerating family member 3 gamma; Pancreatitis-associated protein 1B; PAP-1B]

products gene name :

[REG3G]

products gene name syn :

[PAP1B]

other gene names :

[REG3G; REG3G; PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III; PAP1B; REG-3-gamma; PAP-1B; PAP IB; REG III; Reg III-gamma]

clonality :

Monoclonal

isotype :

IgG1,k

clone :

[1790CT313.66.2]

host :

Mouse

reactivity :

Human

sequence length :

175

specificity :

This REG3G antibody is generated from a mouse immunized with a recombinant protein of human REG3G.

form :

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:1000. IHC-P~~1:25

image1 heading :

Western Blot (WB)

image2 heading :

Testing Data (TD)

other info1 :

Calculated MW: 19330

other info2 :

Cellular Location: Secreted. Cytoplasm. Tissue Location: Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta. Function: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

products categories :

Crown Antibodies; New Antibodies; Primary Antibodies; Immunology

products description :

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

products references :

Nata K.,et al.Gene 340:161-170 (2004). Laurine E.,et al.Biochim. Biophys. Acta 1727:177-187 (2005). Clark H.F.,et al.Genome Res. 13:2265-2270 (2003). Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45 (2004).

ncbi gi num :

56699413

ncbi acc num :

NP_001008388.1

ncbi gb acc num :

NM_001008387.2

uniprot acc num :

Q6UW15

ncbi summary :

This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

uniprot summary :

REG3G: Might be a stress protein involved in the control of bacterial proliferation. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 2p12. Biological Process: defense response to Gram-positive bacterium; MyD88-dependent toll-like receptor signaling pathway; negative regulation of keratinocyte differentiation

size1 :

0.05 mL

price1 :

165 USD

size2 :

0.2 mL

price2 :

370

more info or order :

MyBioSource product webpage