protein

Mouse Nkx2-5 Blocking Peptide (Center)

MBS9229481

0.1 mg

155 USD

Blocking Peptide

Mouse Nkx2-5 Blocking Peptide (Center)

[Nkx2-5]

[Homeobox protein Nkx-25; Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E; Nkx2-5; Csx; Nkx-25; Nkx2e]

[Homeobox protein Nkx-2.5; Homeobox protein Nkx-2.5; homeobox protein Nkx-2.5; NK2 homeobox 5; Cardiac-specific homeobox; Homeobox protein CSX; Homeobox protein NK-2 homolog E]

[Nkx2-5]

[Csx; Nkx-2.5; Nkx2e]

[Nkx2-5; Nkx2-5; Csx; Nkx2.5; tinman; Nkx-2.5; Csx; Nkx-2.5; Nkx2e]

NKX25_MOUSE

318

The synthetic peptide sequence is selected from aa 192-205 of HUMAN Nkx2-5

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Cellular Location: Nucleus

Tissue Location: Predominantly in the adult and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. Together with PBX1, it is required for spleen development through a mechanism that involves CDKN2B repression.

1170294

P42582.1

P42582

34,163 Da

Heart Development Pathway (672437)

NKX2-5: Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Interacts with HIPK1 and HIPK2, but not HIPK3. Interacts with the C-terminal zinc finger of GATA4 through its homeobox domain. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with FBLIM1. Expressed only in the heart. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Cellular Component: cytoplasm; nucleus; transcription factor complex. Molecular Function: chromatin binding; DNA binding; histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding. Biological Process: adult heart development; atrial cardiac muscle cell development; BMP signaling pathway; cardiac muscle cell differentiation; cardiac muscle cell proliferation; cardiac muscle contraction; cardiac muscle development; cardiac muscle morphogensis; cell differentiation; embryonic heart tube development; endoderm development; heart contraction; heart development; heart looping; heart morphogenesis; hemopoiesis; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; pharyngeal system development; positive regulation of cardioblast differentiation; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cardiac muscle cell proliferation; regulation of transcription from RNA polymerase II promoter; sarcomere organization; spleen development; thyroid gland development; tongue development; vasculogenesis; ventricular cardiac muscle cell development; ventricular cardiac myofibril development; Wnt receptor signaling pathway through beta-catenin

0.1 mg

155 USD