catalog number :
MBS9228622
products type :
Blocking Peptide
products full name :
LRIG1 Blocking Peptide (C-term)
products short name :
[LRIG1]
products name syn :
[Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1; LRIG1; LIG1]
other names :
[leucine-rich repeats and immunoglobulin-like domains protein 1; Leucine-rich repeats and immunoglobulin-like domains protein 1; leucine-rich repeats and immunoglobulin-like domains protein 1; leucine rich repeats and immunoglobulin like domains 1]
products gene name :
[LRIG1]
products gene name syn :
[LIG1]
other gene names :
[LRIG1; LRIG1; LIG1; LIG-1; LIG1; LIG-1]
uniprot entry name :
LRIG1_HUMAN
specificity :
The synthetic peptide sequence is selected from aa 816-829 of HUMAN LRIG1
form :
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
storage stability :
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
other info1 :
Cellular Location: Membrane; Single-pass type I membrane protein
other info2 :
Tissue Location: Widely expressed.
products description :
LRIG1 acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
ncbi acc num :
NP_056356.2
ncbi gb acc num :
NM_015541.2
ncbi pathways :
ErbB4 Signaling Events Pathway (137991); Internalization Of ErbB1 Pathway (138013); Signal Transduction Pathway (1269379); Signaling By EGFR Pathway (1269380)
uniprot summary :
LRIG1: a singhle-pass type I membrane protein that acts as a feedback negative regulator of signaling by receptor tyrosine kinases. Regulates cadherin-dependent contact inhibition. Interacts with EGFR, HER2, -3, and -4. Two isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, regulatory subunit; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p14