protein

SEMA3A Antibody (Center) Blocking Peptide

MBS9227230

0.1 mg

155 USD

Blocking Peptide

SEMA3A Antibody (Center) Blocking Peptide

[SEMA3A]

[Semaphorin-3A; Semaphorin III; Sema III; SEMA3A; SEMAD]

[Semaphorin-3A; Semaphorin-3A; semaphorin-3A; semaphorin 3A; Semaphorin III; Sema III]

[SEMA3A]

[SEMAD]

[SEMA3A; SEMA3A; HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; SEMAD; Sema III]

SEM3A_HUMAN

771

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Cellular Location: Secreted. Function: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.

Specificity: The synthetic peptide sequence used to generate the antibody MBS9207933 was selected from the Center region of human SEMA3A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

SEMA3A is a member of the semaphorin family with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

8134674

Q14563.1

Q14563

88,889 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (1270303); CRMPs In Sema3A Signaling Pathway (1270310); Developmental Biology Pathway (1270302); SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway (1270308); Sema3A PAK Dependent Axon Repulsion Pathway (1270309); Semaphorin Interactions Pathway (1270304)

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]

SEMA3A: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. Belongs to the semaphorin family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7p12.1. Cellular Component: axon; extracellular region; extracellular space. Molecular Function: chemorepellent activity; semaphorin receptor binding. Biological Process: axon extension involved in axon guidance; axon guidance; negative regulation of axon extension involved in axon guidance; nerve development; neural crest cell migration; neuron migration; olfactory bulb development; regulation of axon extension involved in axon guidance; sensory system development; sympathetic nervous system development. Disease: Hypogonadotropic Hypogonadism 16 With Or Without Anosmia

0.1 mg

155 USD