PTTG1 Antibody (N-term) Blocking Peptide | MyBioSource MBS9226817 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

PTTG1 Antibody (N-term) Blocking Peptide

catalog :

MBS9226817

quantity :

0.1 mg

price :

155 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9226817

products type :

Blocking Peptide

products full name :

PTTG1 Antibody (N-term) Blocking Peptide

products short name :

[PTTG1]

products name syn :

[Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG; PTTG1; EAP1; PTTG; TUTR1]

other names :

[Securin; Securin; securin; pituitary tumor-transforming 1; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG]

products gene name :

[PTTG1]

products gene name syn :

[EAP1; PTTG; TUTR1]

other gene names :

[PTTG1; PTTG1; EAP1; PTTG; HPTTG; TUTR1; EAP1; PTTG; TUTR1; Tumor-transforming protein 1; hPTTG]

uniprot entry name :

PTTG1_HUMAN

sequence length :

202

specificity :

The synthetic peptide sequence used to generate the antibody AP7354a was selected from the N-term region of human PTTG1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay

form :

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

other info1 :

Cellular Location: Cytoplasm. Nucleus. Clone Names: 80917167. Peptide ID: 80917167

other info2 :

Tissue Location: Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer

products description :

PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus

ncbi gi num :

29336594

ncbi acc num :

O95997.1

uniprot acc num :

O95997

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (1269838); APC/C:Cdc20 Mediated Degradation Of Securin Pathway (1269849); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (1269844); APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway (1269851); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (1269842); Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054); Cell Cycle Pathway (463)

ncbi summary :

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

uniprot summary :

Securin: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family. Protein type: Oncoprotein; Cell cycle regulation. Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: cytoplasm; cytosol. Molecular Function: protease inhibitor activity; protein binding; transcription factor activity. Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; homologous chromosome segregation; protein ubiquitination during ubiquitin-dependent protein catabolic process; spermatogenesis; transcription from RNA polymerase II promoter

size1 :

0.1 mg

price1 :

155 USD

more info or order :

MyBioSource product webpage