protein

TBX2 Antibody (Center) Blocking Peptide

MBS9222358

0.1 mg

155 USD

Blocking Peptide

TBX2 Antibody (Center) Blocking Peptide

[TBX2]

[T-box transcription factor TBX2; T-box protein 2; TBX2]

[T-box transcription factor TBX2; T-box transcription factor TBX2; T-box transcription factor TBX2; T-box 2]

[TBX2]

[TBX2; TBX2; T-box protein 2]

TBX2_HUMAN

[100430147]

712

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Cellular Location: Nucleus {ECO:0000255 PROSITE-ProRule:PRU00201}

Tissue Location: Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.

294862490

Q13207.3

Q13207

75,066 Da

Heart Development Pathway (198802)

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]

TBX2: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 17q23.2. Cellular Component: nucleus. Molecular Function: DNA binding; protein binding; sequence-specific DNA binding. Biological Process: cardiac muscle development; cell aging; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic heart tube development; heart looping; muscle cell fate determination; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; regulation of heart contraction

0.1 mg

155 USD