protein

ASGR1 Antibody (N-term) Blocking Peptide

MBS9221460

0.1 mg

155 USD

Blocking Peptide

ASGR1 Antibody (N-term) Blocking Peptide

[ASGR1]

[Asialoglycoprotein receptor 1; Asialoglycoprotein receptor 1; asialoglycoprotein receptor 1; asialoglycoprotein receptor 1; C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1]

[ASGR1]

[CLEC4H1]

[ASGR1; ASGR1; HL-1; ASGPR; ASGPR1; CLEC4H1; CLEC4H1; ASGP-R 1; ASGPR 1; HL-1]

ASGR1_HUMAN

[100528078]

291

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C

Cellular Location: Isoform H1a: Membrane; Single-pass type II membrane protein. Tissue Location: Expressed exclusively in hepatic parenchymal cells

Partially deglycosylated plasma glycoproteins and immunoglobulin IgA2 allotypes are efficiently and specificallyremoved from circulation by a receptor-mediated process. Theasialoglycoprotein receptor binds to desialylated(galactosyl-terminal) glycoproteins. It transports theseglycoproteins via a series of membrane vesicles and tubules to anacidic-sorting organelle where the receptor and ligand dissociate.Then the receptor is recycled back to the cell surface and theligand is transported to the lysosomes for degradation.Alternatively spliced transcript variants encoding distinctisoforms have been identified.

126132

P07306

P07306

Thyroid Hormone Synthesis Pathway (835410); Thyroid Hormone Synthesis Pathway (839541)

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 17p13.2. Cellular Component: integral to plasma membrane. Molecular Function: asialoglycoprotein receptor activity; protein binding. Biological Process: receptor-mediated endocytosis

0.1 mg

155 USD