protein

TFR2 Antibody (C-term) Blocking peptide

MBS9219135

0.1 mg

155 USD

Blocking Peptide

TFR2 Antibody (C-term) Blocking peptide

[TFR2]

[Transferrin receptor protein 2; TfR2; TFR2]

[Transferrin receptor protein 2; Transferrin receptor protein 2; transferrin receptor protein 2; transferrin receptor 2]

[TFR2]

[TFR2; TFR2; HFE3; TFRC2; TfR2]

TFR2_HUMAN

[100311174]

801

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Cellular Location: Cell membrane; Single-pass type II membrane protein. Peptide: 100311174

Tissue Location: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly

This gene is a member of the transferrin receptor-likefamily and encodes a single-pass type II membrane protein with aprotease associated (PA) domain, an M28 peptidase domain and atransferrin receptor-like dimerization domain. This proteinmediates cellular uptake of transferrin-bound iron and mutations inthis gene have been associated with hereditary hemochromatosis typeIII. Alternatively spliced variants which encode different proteinisoforms have been described; however,not all variants have beenfully characterized

20140912

Q9UP52.1

Q9UP52

Iron Metabolism In Placenta Pathway (672461)

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: cytoplasmic vesicle; external side of plasma membrane; integral to plasma membrane. Molecular Function: glycoprotein binding; protein binding; transferrin receptor activity. Biological Process: cellular iron ion homeostasis; iron ion homeostasis; positive regulation of endocytosis; positive regulation of transcription from RNA polymerase II promoter; receptor-mediated endocytosis; response to iron ion; transferrin transport. Disease: Hemochromatosis, Type 3

0.1 mg

155 USD