Human Complement C1q subcomponent subunit C, C1QC ELISA Kit | MyBioSource MBS921873 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Complement C1q subcomponent subunit C, C1QC ELISA Kit

catalog :

MBS921873

quantity :

24-Strip-Wells (LIMIT 1)

price :

240 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS921873

products type :

ELISA Kit

products full name :

Human Complement C1q subcomponent subunit C, C1QC ELISA Kit

products short name :

[complement component 1, q subcomponent, C chain]

products name syn :

[Human Complement C1q subcomponent subunit C (C1QC) ELISA kit; C1Q-C; C1QG; FLJ27103; OTTHUMP00000002933; complement C1q subcomponent subunit C; complement component 1; q subcomponent; gamma polypeptide; complement component 1; q subcomponent; C chain]

other names :

[complement C1q subcomponent subunit C; Complement C1q subcomponent subunit C; complement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide; complement component 1, q subcomponent, C chain]

products gene name :

[C1QC]

other gene names :

[C1QC; C1QC; C1QG; C1Q-C; C1QG]

uniprot entry name :

C1QC_HUMAN

reactivity :

Human

sequence length :

245

specificity :

This assay has high sensitivity and excellent specificity for detection of Human C1QC. No significant cross-reactivity or interference between Human C1QC and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 9.38 ng/ml-600 ng/ml. Sensitivity: 2.34 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Complement. Protein Biological Process 3: Complement pathway

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for C1QC has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any C1QC present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for C1QC is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of C1QC bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

166235903

ncbi acc num :

NP_001107573.1

ncbi gb acc num :

NM_001114101.1

uniprot acc num :

P02747

ncbi mol weight :

25,774 Da

ncbi pathways :

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

ncbi summary :

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.11. Cellular Component: extracellular space; collagen; extracellular region. Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; negative regulation of granulocyte differentiation; complement activation. Disease: C1q Deficiency

size1 :

24-Strip-Wells (LIMIT 1)

price1 :

240 USD

size2 :

48-Strip-Wells

price2 :

435

size3 :

96-Strip-Wells

price3 :

625

size4 :

5x96-Strip-Wells

price4 :

2595

size5 :

10x96-Strip-Wells

price5 :

4905

more info or order :

MyBioSource product webpage