FAT4 Antibody | MyBioSource MBS9217029 product information

product summary

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company name :

MyBioSource

product type :

antibody

product name :

FAT4 Antibody

catalog :

MBS9217029

quantity :

0.05 mL

price :

165 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Anti-FAT4 Antibody at 1:2000 dilution + Recombinant protein. Lysates/proteins at 20 ug per lane. Secondary. Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 543 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

image 2 :

Anti-FAT4 Antibody at 1:2000 dilution + Recombinant protein. Lysates/proteins at 20 ug per lane. Secondary. Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 543 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

image 3 :

Anti-FAT4 Antibody at 1:2000 dilution + Recombinant protein. Lysates/proteins at 20 ug per lane. Secondary. Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 543 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

product information

catalog number :

MBS9217029

products type :

Antibody

products full name :

FAT4 Antibody

products short name :

[FAT4]

products name syn :

[Protocadherin Fat 4; hFat4; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT4; CDHF14; FATJ]

other names :

[protocadherin Fat 4 isoform 2; Protocadherin Fat 4; protocadherin Fat 4; FAT atypical cadherin 4; Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J]

products gene name :

[FAT4]

products gene name syn :

[CDHF14; FATJ]

other gene names :

[FAT4; FAT4; FATJ; FAT-J; CDHF14; CDHR11; HKLLS2; VMLDS2; NBLA00548; CDHF14; FATJ; hFat4]

uniprot entry name :

FAT4_HUMAN

clonality :

Monoclonal

isotype :

IgG1,k

host :

Mouse

reactivity :

Human

sequence length :

4982

specificity :

This FAT4 antibody is generated from a mouse immunized with a recombinant protein between 4500-4786 amino acids from human FAT4.

form :

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB:~~1:2000

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Western Blot (WB)

other info1 :

Subtitle: Purified Mouse Monoclonal Antibody (Mab). Cellular Location: Membrane; Single-pass type I membrane protein. Note=In the kidney, localizes to primary cilia. Clone Names: 1654CT645.1.70

other info2 :

Tissue Location: Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. Antigen Type: Recombinant Protein

products categories :

New Antibodies; Primary Antibodies; Cancer; Signal Transduction

products description :

Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).

products references :

Hoeng J.C.,et al.J. Mol. Biol. 337:307-317 (2004). Hillier L.W.,et al.Nature 434:724-731 (2005). Ohira M.,et al.Cancer Lett. 197:63-68 (2003). Ota T.,et al.Nat. Genet. 36:40-45 (2004). Bechtel S.,et al.BMC Genomics 8:399-399 (2007).

ncbi gi num :

603844373

ncbi acc num :

NP_001278214.1

ncbi gb acc num :

NM_001291285.1

uniprot acc num :

Q6V0I7

ncbi mol weight :

542687 Da

ncbi summary :

The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]

uniprot summary :

FAT4: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: 4q28.1. Cellular Component: apical part of cell; integral to membrane; intracellular; plasma membrane. Molecular Function: calcium ion binding; protein binding. Biological Process: cerebral cortex development; gut development; heart morphogenesis; heterophilic cell adhesion; homophilic cell adhesion; inner ear receptor stereocilium organization and biogenesis; neurogenesis; plasma membrane organization and biogenesis; ureteric bud branching. Disease: Hennekam Lymphangiectasia-lymphedema Syndrome 2; Van Maldergem Syndrome 2

size1 :

0.05 mL

price1 :

165 USD

size2 :

0.2 mL

price2 :

370

more info or order :

MyBioSource product webpage