NAT8L Antibody (N-Term) | MyBioSource MBS9216916 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NAT8L Antibody (N-Term)

catalog :

MBS9216916

quantity :

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price :

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clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA

more info or order :

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image

image 1 :

All lanes : Anti-NAT8L Antibody (N-Term) at 1:2000 dilution. Lane 1: 293T/17 whole cell lysate. Lane 2: mouse brain lysate. Lane 3: SH-SY5Y whole cell lysate. Lysates/proteins at 20 ug per lane. Secondary. Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

product information

catalog number :

MBS9216916

products type :

Antibody

products full name :

NAT8L Antibody (N-Term)

products short name :

[NAT8L]

products name syn :

[Purified Rabbit Polyclonal Antibody (Pab); N-acetylaspartate synthetase; NAA synthetase; 2.3.1.17; Camello-like protein 3; N-acetyltransferase 8-like protein; NAT8L; CML3]

other names :

[N-acetylaspartate synthetase; N-acetylaspartate synthetase; N-acetylaspartate synthetase; N-acetyltransferase 8-like (GCN5-related, putative); Camello-like protein 3; N-acetyltransferase 8-like protein]

products gene name :

[NAT8L]

other gene names :

[NAT8L; NAT8L; CML3; NACED; NAT8-LIKE; CML3; NAA synthetase]

uniprot entry name :

NAT8L_HUMAN

clonality :

Polyclonal

isotype :

host :

Rabbit

reactivity :

Human, Mouse . Predicted: Rat

sequence length :

302

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA

app notes :

WB~~1:2000

image1 heading :

Western Blot (WB)

other info1 :

Target/Specificity: This NAT8L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 59-93 amino acids from human NAT8L. Calculated MW: 32837

other info2 :

Antigen Type: Synthesized Peptide. Cellular Location : Cytoplasm. Membrane; Single- pass membrane protein. Microsome membrane; Single-pass membrane protein Mitochondrion membrane; Single-pass membrane protein. Rough endoplasmic reticulum membrane; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment. Tissue Location: Expressed in brain.

products categories :

Metabolism; Signal Transduction

products description :

Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.

products references :

Hillier L.W.,et al.Nature 434:724-731(2005). Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004). Ota T.,et al.Nat. Genet. 36:40-45(2004). Popsueva A.E.,et al.Dev. Biol. 234:483-496(2001). Arun P.,et al.Neurochem. Int. 55:219-225(2009).

ncbi gi num :

263192221

ncbi acc num :

NP_848652.2

ncbi gb acc num :

NM_178557.3

uniprot acc num :

Q8N9F0

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Metabolic Pathways (132956); Metapathway Biotransformation (198837)

ncbi summary :

This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010]

uniprot summary :

NAT8L: Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. Defects in NAT8L are the cause of N-acetylaspartate deficiency (NACED). A metabolic disorder resulting in truncal ataxia, marked developmental delay, seizures, and secondary microcephaly. Belongs to the camello family. Protein type: EC 2.3.1.17; Membrane protein, integral; Acetyltransferase. Chromosomal Location of Human Ortholog: 4p16.3. Cellular Component: cytoplasm; integral to membrane; mitochondrial membrane; mitochondrion; rough endoplasmic reticulum membrane. Molecular Function: aspartate N-acetyltransferase activity. Biological Process: metabolic process. Disease: N-acetylaspartate Deficiency

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price1 :

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more info or order :

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