SDHC Antibody (C-Term) | MyBioSource MBS9216068 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SDHC Antibody (C-Term)

catalog :

MBS9216068

quantity :

0.05 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes : Anti-SDHC Antibody (C-Term) at 1:2000 dilution. Lane 1: human skeletal muscle lysate. Lane 2: mouse heart lysate. Lane 3: mouse kidney lysate. Lysates/proteins at 20 ug per lane. Secondary. Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 19 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

product information

catalog number :

MBS9216068

products type :

Antibody

products full name :

SDHC Antibody (C-Term)

products short name :

[SDHC]

products name syn :

[Purified Rabbit Polyclonal Antibody (Pab); Succinate dehydrogenase cytochrome b560 subunit; mitochondrial; Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL; SDHC; CYB560; SDH3]

other names :

[succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 2; Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; succinate dehydrogenase cytochrome b560 subunit, mitochondrial; succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL]

products gene name :

[SDHC]

other gene names :

[SDHC; SDHC; CYBL; PGL3; QPS1; SDH3; CYB560; CYB560; SDH3; QPs1; CYBL]

uniprot entry name :

C560_HUMAN

clonality :

Polyclonal

isotype :

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

150

specificity :

This SDHC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 113-144 amino acids from human SDHC.

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB ~~ 1:2000

image1 heading :

Western Blot (WB)

other info1 :

Cellular location: Mitochondrion inner membrane; Multi-pass membrane protein. Calculated MW: 18610

products categories :

Cell Biology; Developmental Biology; Metabolism; Signal Transduction

products description :

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

products references :

Au H.C.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases. Hirawake H.,et al.Cytogenet. Cell Genet. 79:132-138(1997). Elbehti-Green A.,et al.Gene 213:133-140(1998). Wohllk N.,et al.Mol. Genet. Metab. 65:187-190(1998). Hiatomi H.,et al.Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.

ncbi gi num :

78711820

ncbi acc num :

NP_001030588.1

ncbi gb acc num :

NM_001035511.1

uniprot acc num :

Q99643

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Biosynthesis Of Antibiotics Pathway (1144997); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Citrate Cycle (TCA Cycle) Pathway (82927); Citrate Cycle (TCA Cycle) Pathway (288); Citric Acid Cycle (TCA Cycle) Pathway (1270125); Electron Transport Chain Pathway (198860); Huntington's Disease Pathway (83100)

ncbi summary :

This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

uniprot summary :

SDHC: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHC are the cause of paragangliomas type 3 (PGL3). A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas are most commonly located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. Defects in SDHC are a cause of paraganglioma and gastric stromal sarcoma (PGGSS); also known as Carney- Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Belongs to the cytochrome b560 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial. Chromosomal Location of Human Ortholog: 1q23.3. Cellular Component: mitochondrial respiratory chain complex II; mitochondrion; mitochondrial inner membrane; integral to membrane. Molecular Function: succinate dehydrogenase (ubiquinone) activity; electron carrier activity; metal ion binding; heme binding. Biological Process: cellular metabolic process; mitochondrial electron transport, succinate to ubiquinone; tricarboxylic acid cycle; aerobic respiration. Disease: Gastrointestinal Stromal Tumor; Paraganglioma And Gastric Stromal Sarcoma; Paragangliomas 3

size1 :

0.05 mL

price1 :

165 USD

size2 :

0.2 mL

price2 :

370

more info or order :

MyBioSource product webpage