BCL6 Antibody (Center) | MyBioSource MBS9215821 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BCL6 Antibody (Center)

catalog :

MBS9215821

quantity :

0.05 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9215821

products type :

Antibody

products full name :

BCL6 Antibody (Center)

products short name :

BCL6

products name syn :

Purified Rabbit Polyclonal Antibody (Pab); B-cell lymphoma 6 protein, BCL-6, B-cell lymphoma 5 protein, BCL-5, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, BCL6, BCL5, LAZ3, ZBTB27, ZNF51

other names :

B-cell lymphoma 6 protein isoform 1; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein; B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

products gene name :

BCL6

other gene names :

BCL6; BCL6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; BCL5; LAZ3; ZBTB27; ZNF51; BCL-6; BCL-5

uniprot entry name :

BCL6_HUMAN

clonality :

Polyclonal

isotype :

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

706

specificity :

This BCL6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 364-395 amino acids from the Central region of human BCL6.

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

0.3mg/ml

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), ELISA

app notes :

IHC-P ~~ 1:25. WB ~~ 1:1000

other info1 :

Antigen Source: Human

other info2 :

Cellular Location: Nucleus. Tissue Location: Expressed in germinal center T- and B-cells and in primary immature dendritic cells

products categories :

Crown Antibodies; Cancer

products description :

Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53- dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH- dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

products references :

Kerckaert J.-P.,et al.Nat. Genet. 5:66-70(1993). Ye B.H.,et al.Science 262:747-750(1993). Miki T.,et al.Blood 83:26-32(1994). Baron B.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:5262-5266(1993). Mao Y.,et al.Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.

ncbi gi num :

195927002

ncbi acc num :

NP_001124317.1

ncbi gb acc num :

NM_001130845.1

uniprot acc num :

P41182

ncbi mol weight :

78846

ncbi pathways :

B Cell Receptor Signaling Pathway (198909); DNA Damage Response (only ATM Dependent) Pathway (198827); Direct P53 Effectors Pathway (137939); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); IL4-mediated Signaling Events Pathway (137933); Signaling Events Mediated By HDAC Class II Pathway (138062); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

size1 :

0.05 mL

price1 :

155 USD

size2 :

0.2 mL

price2 :

340

more info or order :

MyBioSource product webpage