KCNJ6 Antibody (Center) | MyBioSource MBS9215167 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

KCNJ6 Antibody (Center)

catalog :

MBS9215167

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, flow cytometry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

KCNJ6 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KCNJ6 antibody detected the KCNJ6 protein (arrow).

image 2 :

KCNJ6 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the KCNJ6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

image 3 :

KCNJ6 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

product information

catalog number :

MBS9215167

products type :

Antibody

products full name :

KCNJ6 Antibody (Center)

products short name :

[KCNJ6]

products name syn :

[G protein-activated inward rectifier potassium channel 2; GIRK-2; BIR1; Inward rectifier K(+) channel Kir32; KATP-2; Potassium channel; inwardly rectifying subfamily J member 6; KCNJ6; GIRK2; KATP2; KCNJ7]

other names :

[G protein-activated inward rectifier potassium channel 2; G protein-activated inward rectifier potassium channel 2; G protein-activated inward rectifier potassium channel 2; potassium channel, inwardly rectifying subfamily J, member 6; BIR1; Inward rectifier K(+) channel Kir3.2; KATP-2; Potassium channel, inwardly rectifying subfamily J member 6]

products gene name :

[KCNJ6]

other gene names :

[KCNJ6; KCNJ6; BIR1; GIRK2; KATP2; KCNJ7; KPLBS; GIRK-2; KATP-2; KIR3.2; hiGIRK2; GIRK2; KATP2; KCNJ7; GIRK-2]

uniprot entry name :

KCNJ6_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Mouse, Rat)

sequence positions :

[26-55]

sequence length :

423

specificity :

This KCNJ6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human KCNJ6.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

WB, IHC-P, FC, E

app notes :

WB~~1:1000. IHC-P ~~1:50~100. FC~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Flow Cytometry (FC/FACS)

other info1 :

Calculated MW: 48451

other info2 :

Function: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their oltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to morepositive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium . Cellular location: Membrane; Multi-pass membrane protein. Tissue Location: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas

products categories :

Neuroscience

ncbi gi num :

4504843

ncbi acc num :

NP_002231.1

ncbi gb acc num :

NM_002240.4

uniprot acc num :

P48051

ncbi summary :

This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]

uniprot summary :

GIRK2: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily. Protein type: Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 21q22.1. Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; plasma membrane. Molecular Function: protein binding; G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity. Biological Process: synaptic transmission; potassium ion import; potassium ion transport. Disease: Keppen-lubinsky Syndrome

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage