HIST1H2BC/HIST1H2BF Antibody (N-term) | MyBioSource MBS9215123 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HIST1H2BC/HIST1H2BF Antibody (N-term)

catalog :

MBS9215123

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, cow

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

HIST1H2BC/HIST1H2BF Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the HIST1H2BC/HIST1H2BF antibody detected the HIST1H2BC/HIST1H2BF protein (arrow).

product information

catalog number :

MBS9215123

products type :

Antibody

products full name :

HIST1H2BC/HIST1H2BF Antibody (N-term)

products short name :

[HIST1H2BC/HIST1H2BF]

products name syn :

[Histone H2B type 1-C/E/F/G/I; Histone H2B1 A; Histone H2Ba; H2B/a; Histone H2Bg; H2B/g; Histone H2Bh; H2B/h; Histone H2Bk; H2B/k; Histone H2Bl; H2B/l; HIST1H2BC; H2BFL]

other names :

[histone H2B type 1-C/E/F/G/I; Histone H2B type 1-C/E/F/G/I; histone H2B type 1-C/E/F/G/I; histone cluster 1, H2bg; Histone H2B.1 A; Histone H2B.a; H2B/a; Histone H2B.g; H2B/g; Histone H2B.h; H2B/h; Histone H2B.k; H2B/k; Histone H2B.l; H2B/l]

products gene name :

[HIST1H2BC]

other gene names :

[HIST1H2BG; HIST1H2BC; H2B/a; H2BFA; H2B.1A; dJ221C16.8; H2BFL; H2B/a; H2B/g; H2B/h; H2B/k; H2B/l]

uniprot entry name :

H2B1C_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Xenopus, Mouse, Bovine, Monkey, Chicken, Zebrafish)

sequence positions :

[1-30]

sequence length :

126

specificity :

This HIST1H2BC/HIST1H2BF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BC/HIST1H2BF.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Calculated MW: 13906

other info2 :

Function: Core component of nucleosome.Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Cellular location: Nucleus. Chromosome.

products description :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.

products references :

Kim, S.C., et al. Mol. Cell 23(4):607-618(2006). Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006). Pavri, R., et al. Cell 125(4):703-717(2006). Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006). Siuti, N., et al. J. Proteome Res. 5(2):233-239(2006)

ncbi gi num :

4504257

ncbi acc num :

NP_003509.1

ncbi gb acc num :

NM_003518.3

uniprot acc num :

P62807

ncbi summary :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jan 2015]

uniprot summary :

H2B1C: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p22.1. Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleus. Molecular Function: DNA binding; protein heterodimerization activity. Biological Process: nucleosome assembly; defense response to Gram-positive bacterium; establishment and/or maintenance of chromatin architecture; innate immune response in mucosa; antibacterial humoral response

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage