catalog number :
MBS9214911
products full name :
RARRES3 Antibody (Center)
products short name :
[RARRES3]
products name syn :
[Retinoic acid receptor responder protein 3; 311-; HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein; Tazarotene-induced gene 3 protein; RARRES3; RIG1; TIG3]
other names :
[retinoic acid receptor responder protein 3; Retinoic acid receptor responder protein 3; retinoic acid receptor responder protein 3; retinoic acid receptor responder (tazarotene induced) 3; HRAS-like suppressor 4; HRSL4; RAR-responsive protein TIG3; Retinoid-inducible gene 1 protein; Tazarotene-induced gene 3 protein]
products gene name :
[RARRES3]
other gene names :
[RARRES3; RARRES3; RIG1; TIG3; HRSL4; HRASLS4; PLA1/2-3; RIG1; TIG3; HRSL4]
uniprot entry name :
HRSL4_HUMAN
sequence positions :
[43-71]
specificity :
This RARRES3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-71 amino acids from the Central region of human RARRES3.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
image1 heading :
Western Blot (WB)
other info1 :
Cellular location: Membrane; Single-pass membrane protein. Tissue location: Widely expressed.
other info2 :
Calculated MW: 18179
products categories :
Cancer; Cell Biology
products description :
Retinoids exert biologic effects such as potent growth. inhibitory and cell differentiation activities and are used in the. treatment of hyperproliferative dermatological diseases. These. effects are mediated by specific nuclear receptor proteins that are. members of the steroid and thyroid hormone receptor superfamily of. transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes. whose expression is upregulated by the synthetic retinoid. tazarotene. RARRES3 is thought act as a tumor suppressor or growth. regulator.
products references :
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Uyama, T., et al. Biochim. Biophys. Acta 1791(12):1114-1124(2009). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Higuchi, E., et al. Oncogene 22(30):4627-4635(2003)
ncbi acc num :
NP_004576.2
ncbi gb acc num :
NM_004585.4
ncbi summary :
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
uniprot summary :
RARRES3: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. N- and O-acylation activity is hardly detectable. Belongs to the H-rev107 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.1.-; Cell cycle regulation. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: integral to membrane. Molecular Function: phospholipase A2 activity; protein binding. Biological Process: negative regulation of cell proliferation; phospholipid metabolic process; lipid catabolic process