GP1BA (Glycocalicin) Antibody (Center) | MyBioSource MBS9214443 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GP1BA (Glycocalicin) Antibody (Center)

catalog :

MBS9214443

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of lysates from HUVEC cell line, human placenta and spleen tissue lysate(from left to right), using GP1BA(Glycocalicin) Antibody (Center). MBS9214443 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

product information

catalog number :

MBS9214443

products type :

Antibody

products full name :

GP1BA (Glycocalicin) Antibody (Center)

products short name :

[GP1BA (Glycocalicin)]

products name syn :

[Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; CD42b; Glycocalicin; GP1BA]

other names :

[platelet glycoprotein Ib alpha chain; Platelet glycoprotein Ib alpha chain; platelet glycoprotein Ib alpha chain; glycoprotein Ib (platelet), alpha polypeptide; Antigen CD42b-alpha; CD_antigen: CD42b]

products gene name :

[GP1BA]

other gene names :

[GP1BA; GP1BA; BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; CD42b-alpha; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha]

uniprot entry name :

GP1BA_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

sequence length :

652

specificity :

This GP1BA(Glycocalicin) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 344-378 amino acids from the Central region of human GP1BA(Glycocalicin).

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Calculated MW: 71540. Cellular location: Membrane; Single-pass type I membrane protein

products categories :

Crown Antibodies; Cardiovascular; Immunology; Metabolism

products description :

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

products references :

Lopez J.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5615-5619(1987). Wenger R.H.,et al.Biochem. Biophys. Res. Commun. 156:389-395(1988). Matsubara Y.,et al.Thromb. Haemost. 87:867-872(2002). Matsubara Y.,et al.J. Thromb. Haemost. 1:2198-2205(2003). Titani K.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5610-5614(1987).

ncbi gi num :

291190772

ncbi acc num :

NP_000164.5

ncbi gb acc num :

NM_000173.6

uniprot acc num :

P07359

ncbi pathways :

Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811); Nitrogen Metabolism Pathway (2811)

ncbi summary :

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

uniprot summary :

GPIbA: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Genetic variations in GP1BA may be a cause of susceptibility to non-arteritic anterior ischemic optic neuropathy (NAION). NAION is an ocular disease due to ischemic injury to the optic nerve. It usually affects the optic disk and leads to visual loss and optic disk swelling of a pallid nature. Visual loss is usually sudden, or over a few days at most and is usually permanent, with some recovery possibly occurring within the first weeks or months. Patients with small disks having smaller or non-existent cups have an anatomical predisposition for non-arteritic anterior ischemic optic neuropathy. As an ischemic episode evolves, the swelling compromises circulation, with a spiral of ischemia resulting in further neuronal damage. Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. Defects in GP1BA are the cause of benign mediterranean macrothrombocytopenia (BMM); also known as autosomal dominant benign Bernard-Soulier syndrome. BMM is characterized by mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count. Defects in GP1BA are the cause of pseudo-von Willebrand disease (VWDP). A bleeding disorder is caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal of vWF from the circulation. Protein type: Cell adhesion; Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 17p13.2. Cellular Component: anchored to external side of plasma membrane; cell surface; membrane; integral to plasma membrane; plasma membrane. Molecular Function: protein binding; thrombin receptor activity. Biological Process: platelet activation; fibrinolysis; cell surface receptor linked signal transduction; regulation of blood coagulation; cell morphogenesis; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway. Disease: Pseudo-von Willebrand Disease; Bernard-soulier Syndrome; Bernard-soulier Syndrome, Type A2, Autosomal Dominant; Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage