MPST Antibody (N-term) | MyBioSource MBS9214145 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MPST Antibody (N-term)

catalog :

MBS9214145

quantity :

0.08 mL

price :

155 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9214145

products type :

Antibody

products full name :

MPST Antibody (N-term)

products short name :

MPST

products name syn :

3-mercaptopyruvate sulfurtransferase; MST; MPST; TST2

other names :

3-mercaptopyruvate sulfurtransferase isoform 2; 3-mercaptopyruvate sulfurtransferase; 3-mercaptopyruvate sulfurtransferase; mercaptopyruvate sulfurtransferase

products gene name :

MPST

other gene names :

MPST; MPST; MST; TST2; TUM1; TST2; MST

uniprot entry name :

THTM_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Mouse, Rat)

sequence positions :

24-53

sequence length :

317

specificity :

This MPST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human MPST.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

concentration :

Vial Concentration: 2

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)

app notes :

WB~~1:1000. FC~~1:10~50

other info1 :

Antigen Type: Synthetic Peptide. Primary Accession: P25325. Other Accession: P97532, Q99J99. Function: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions (By similarity). Cellular Location: Cytoplasm. Mitochondrion. Cell junction, synapse, synaptosome

other info2 :

Antigen Source: HUMAN

products categories :

Metabolism; Signal Transduction

products description :

MPST catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU).

products references :

Billaut-Laden,I., Toxicol. Lett. 165 (2), 101-111 (2006)

ncbi gi num :

61835204

ncbi acc num :

NP_001013454.1

ncbi gb acc num :

NM_001013436.2

uniprot acc num :

P25325

ncbi mol weight :

33178

ncbi summary :

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

MPST: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis. Protein type: Mitochondrial; Amino Acid Metabolism - cysteine and methionine; Transferase; EC 2.8.1.2. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: neuron projection; mitochondrial inner membrane; synapse; cell junction. Molecular Function: 3-mercaptopyruvate sulfurtransferase activity; thiosulfate sulfurtransferase activity. Biological Process: cyanate catabolic process; response to toxin

size1 :

0.08 mL

price1 :

155 USD

size2 :

0.4 mL

price2 :

340

more info or order :

MyBioSource product webpage