product summary
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company name :
MyBioSource
product type :
antibody
product name :
DEGS2 Antibody (C-term)
catalog :
MBS9213890
quantity :
0.08 mL
price :
165 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry - paraffin section
more info or order :
image
image 1 :
DEGS2 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DEGS2 antibody detected the DEGS2 protein (arrow).
image 2 :
DEGS2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DEGS2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
product information
catalog number :
MBS9213890
products type :
Antibody
products full name :
DEGS2 Antibody (C-term)
products short name :
[DEGS2]
products name syn :
[Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; 1---; 114--; Degenerative spermatocyte homolog 2; DEGS2 HGNC:20113); C14orf66]
other names :
[sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; delta(4)-desaturase, sphingolipid 2; Degenerative spermatocyte homolog 2]
products gene name :
[DEGS2]
other gene names :
[DEGS2; DEGS2; DES2; FADS8; C14orf66]
uniprot entry name :
DEGS2_HUMAN
clonality :
Polyclonal
isotype :
Rabbit Ig
host :
Rabbit
reactivity :
Human (Predicted Reactivity: Bovine, Mouse)
sequence positions :
[261-290]
sequence length :
323
specificity :
This DEGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-290 amino acids from the C-terminal region of human DEGS2.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
WB, IHC-P,E
app notes :
WB~~1:1000. IHC-P~~1:50~100
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Function: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
other info2 :
Cellular Location: Endoplasmic reticulum membrane{ECO:0000250 UniProtKB:Q8R2F2};Multi-pass membrane protein {ECO:0000250 UniProtKB:Q8R2F2}. Tissue Location: Highly expressed in skin, intestine and kidney.
products description :
DEGS2 encodes a bifunctional enzyme that is involved. in the biosynthesis of phytosphingolipids in human skin and in. other phytosphingolipid-containing tissues. This enzyme can act as. a sphingolipid delta(4)-desaturase, and also as a sphingolipid. C4-hydroxylase.
products references :
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005). Mizutani, Y., et al. FEBS Lett. 563 (1-3), 93-97 (2004) :
ncbi gi num :
207113139
ncbi acc num :
NP_996801.2
ncbi gb acc num :
NM_206918.2
uniprot acc num :
Q6QHC5
ncbi mol weight :
37197
ncbi pathways :
, Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099); , Pathway (123099)
ncbi summary :
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
uniprot summary :
DEGS2: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. Belongs to the fatty acid desaturase family. DEGS subfamily. Protein type: EC 1.14.-.-; Membrane protein, integral; EC 1.-.-.-; Oxidoreductase; Lipid Metabolism - sphingolipid; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 14q32.2. Cellular Component: endoplasmic reticulum membrane; integral to membrane. Molecular Function: sphingosine hydroxylase activity; sphingolipid delta-4 desaturase activity. Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; ceramide biosynthetic process; sphinganine metabolic process
size1 :
0.08 mL
price1 :
165 USD
size2 :
0.4 mL
price2 :
370
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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