ALDH1A3 Antibody (N-term) | MyBioSource MBS9213574 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ALDH1A3 Antibody (N-term)

catalog :

MBS9213574

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

ALDH1A3 Antibody (N-term) western blot analysis in 293,Y79 cell line lysates (35ug/lane).This demonstrates the ALDH1A3 antibody detected the ALDH1A3 protein (arrow).

image 2 :

Formalin-fixed and paraffin-embedded human kideny tissue reacted with ALDH1A3 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

product information

catalog number :

MBS9213574

products type :

Antibody

products full name :

ALDH1A3 Antibody (N-term)

products short name :

[ALDH1A3]

products name syn :

[Aldehyde dehydrogenase family 1 member A3; Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; ALDH1A3; ALDH6]

other names :

[aldehyde dehydrogenase family 1 member A3 isoform 1; Aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase 1 family, member A3; Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3]

products gene name :

[ALDH1A3]

other gene names :

[ALDH1A3; ALDH1A3; ALDH6; MCOP8; RALDH3; ALDH1A6; ALDH6; RALDH-3; RalDH3]

uniprot entry name :

AL1A3_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, mouse

sequence positions :

[24-51]

sequence length :

512

specificity :

This ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human ALDH1A3.

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

concentration :

Vial Concentration: 2

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

WB~~1:1000. IHC-P~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Antigen Type: Synthetic Peptide. Crown Antibody: Yes

other info2 :

Antigen Source: HUMAN. Function: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity). Cellular Location: Cytoplasm. Tissue Location: Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.

products categories :

Crown Antibodies; Metabolism; Neuroscience; Signal Transduction

products description :

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.

products references :

Rexer,B.N., Cancer Res. 61 (19), 7065-7070 (2001). Yoshida,A., Eur. J. Biochem. 251 (3), 549-557 (1998)

ncbi gi num :

153266822

ncbi acc num :

NP_000684.2

ncbi gb acc num :

NM_000693.3

uniprot acc num :

P47895

ncbi mol weight :

56108

ncbi pathways :

D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220); D-galactarate Degradation I Pathway (220)

ncbi summary :

This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

uniprot summary :

ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family. Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - histidine; EC 1.2.1.5; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: cytoplasm; cytosol. Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity. Biological Process: inner ear morphogenesis; retinal metabolic process; embryonic eye morphogenesis; righting reflex; retinol metabolic process; positive regulation of apoptosis; olfactory pit development; optic cup morphogenesis involved in camera-type eye development; retinoic acid metabolic process; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development. Disease: Microphthalmia, Isolated 8

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage