MAFA Antibody (C-term) | MyBioSource MBS9213357 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAFA Antibody (C-term)

catalog :

MBS9213357

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

MAFA Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MAFA antibody detected the MAFA protein (arrow).

product information

catalog number :

MBS9213357

products type :

Antibody

products full name :

MAFA Antibody (C-term)

products short name :

[MAFA]

products name syn :

[Transcription factor MafA; Pancreatic beta-cell-specific transcriptional activator; Transcription factor RIPE3b1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A; MAFA]

other names :

[transcription factor MafA; Transcription factor MafA; transcription factor MafA; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; Pancreatic beta-cell-specific transcriptional activator; Transcription factor RIPE3b1; V-maf musculoaponeurotic fibrosarcoma oncogene homolog A]

products gene name :

[MAFA]

other gene names :

[MAFA; MAFA; hMafA; RIPE3b1]

uniprot entry name :

MAFA_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human . Predicted Reactivity: Mouse

sequence positions :

[286-315]

sequence length :

353

specificity :

This MAFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of human MAFA.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

products categories :

Cancer; Signal Transduction

products description :

MAFA is a transcription factor that binds RIPE3b, a. conserved enhancer element that regulates pancreatic beta. cell-specific expression of the insulin gene (INS; MIM 176730). (Olbrot et al., 2002 [PubMed 12011435]).

products references :

Lecoin, L., et al. Dev Neurobiol 70(7):485-497(2010). Guo, S., et al. J. Biol. Chem. 285(17):12655-12661(2010). Kondo, T., et al. Mol. Endocrinol. 23(8):1281-1290(2009). Kaneto, H., et al. Adv. Drug Deliv. Rev. 61 (7-8), 489-496 (2009) :. Garin, I., et al. Diabet. Med. 26(7):746-748(2009)

ncbi gi num :

71274111

ncbi acc num :

NP_963883.2

ncbi gb acc num :

NM_201589.3

uniprot acc num :

Q8NHW3

ncbi pathways :

Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692); Thiamine Biosynthesis, AIR = Thiamine-P/thiamine-2P Pathway (389692)

ncbi summary :

MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]

uniprot summary :

MAFA: Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds DNA as a homodimer (Probable). Interacts with NEUROD1, PCAF and PDX1. Up-regulated by glucose. Belongs to the bZIP family. Maf subfamily. Protein type: Tumor suppressor; DNA-binding; Oncoprotein; Transcription factor. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: nucleus. Molecular Function: protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription factor activity. Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; insulin secretion; response to glucose stimulus; positive regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage