antibody

CDK5R1 Antibody (N-term)

MBS9213336

0.08 mL

155 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

CDK5R1 Antibody (N-term)

CDK5R1

Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Cyclin-dependent kinase 5 activator 1; p35; p35; Cyclin-dependent kinase 5 activator 1; p25; p25; Tau protein kinase II 23 kDa subunit; p23; CDK5R1; CDK5R; NCK5A

cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit

CDK5R1

CDK5R1; CDK5R1; p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a; CDK5R; NCK5A; CDK5 activator 1; p35; p25; p23

CD5R1_HUMAN

Polyclonal

Rabbit Ig

Rabbit

Human, mouse

307

This CDK5R1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 30-64 amino acids from the N-terminal region of human CDK5R1.

Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.309

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB), ELISA (EIA)

WB~~1:2000

Cellular Location: Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. Tissue Location: Brain and neuron specific.

Antigen Source: HUMAN

Cell Biology; Neuroscience; Signal Transduction

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Tsai L.-H.,et al.Nature 371:419-423(1994). Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Patrick G.N.,et al.Nature 402:615-622(1999). Kerokoski P.,et al.Brain Res. Mol. Brain Res. 106:50-56(2002).

4502737

NP_003876.1

NM_003885.2

Q15078

34060

Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851); Ribosome Pathway (8851)

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

CDK5R1: activator of cyclin-dependent kinase 5 (CDK5). Required for proper development of the central nervous system. The p35 form of this protein is cleaved by calpain, generating a p25 form, resulting in the prolonged activation and relocalization of the CDK5 from the cell periphery to nuclear and perinuclear regions. The p25 form accumulates in the brain neurons of patients with Alzheimer s disease, leading to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer s disease. Protein type: Protein kinase, regulatory subunit. Chromosomal Location of Human Ortholog: 17q11.2. Cellular Component: contractile fiber; intracellular membrane-bound organelle; cyclin-dependent protein kinase 5 activator complex; postsynaptic density; dendrite; dendritic spine; cytosol; nucleoplasm; growth cone; cell soma; membrane; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; neuromuscular junction; nucleus. Molecular Function: protein serine/threonine kinase activator activity; protein binding; ephrin receptor binding; cyclin-dependent protein kinase activity; cadherin binding; cyclin-dependent protein kinase 5 activator activity; kinase activity; calcium ion binding; protein kinase binding; protein kinase activity. Biological Process: superior olivary nucleus maturation; axon guidance; regulation of neuron differentiation; rhythmic process; neuron migration; negative regulation of axon extension; neuron differentiation; positive regulation of neuron apoptosis; ephrin receptor signaling pathway; cerebellum development; neuron adhesion; neurite development; layer formation in the cerebral cortex; serine phosphorylation of STAT3 protein; acetylcholine receptor signaling, muscarinic pathway; hippocampus development; peptidyl-threonine phosphorylation; axonal fasciculation; cell proliferation; peptidyl-serine phosphorylation; embryonic development; ionotropic glutamate receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of cyclin-dependent protein kinase activity; brain development; negative regulation of transcription, DNA-dependent

0.08 mL

155 USD