product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
MICAL2 Antibody (N-term)
catalog :
MBS9213087
quantity :
0.08 mL
price :
165 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
image
image 1 :
Western blot analysis of MICAL2 Antibody (N-term) in WiDr cell line lysates (35ug/lane). MICAL2 (arrow) was detected using the purified Pab.
product information
catalog number :
MBS9213087
products type :
Antibody
products full name :
MICAL2 Antibody (N-term)
products short name :
[MICAL2]
products name syn :
[Protein-methionine sulfoxide oxidase MICAL2; 11413-; Molecule interacting with CasL protein 2; MICAL-2; MICAL2; KIAA0750; MICAL2PV1; MICAL2PV2]
other names :
[protein-methionine sulfoxide oxidase MICAL2 isoform a; Protein-methionine sulfoxide oxidase MICAL2; protein-methionine sulfoxide oxidase MICAL2; microtubule associated monooxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2; MICAL-2]
products gene name :
[MICAL2]
other gene names :
[MICAL2; MICAL2; MICAL-2; MICAL2PV1; MICAL2PV2; KIAA0750; MICAL2PV1; MICAL2PV2; MICAL-2]
uniprot entry name :
MICA2_HUMAN
clonality :
Polyclonal
isotype :
Rabbit Ig
host :
Rabbit
reactivity :
Human
sequence positions :
[55-83]
sequence length :
955
specificity :
This MICAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human MICAL2.
purity :
Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB~~1:1000
image1 heading :
Western Blot (WB)
other info1 :
Calculated MW: 126689
other info2 :
Function: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through theaddition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Actsas a key regulator of the SRF signalingpathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading toincrease MKL1/MRTF-A presence in thenucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activateSRF:MKL1/MRTF-A through RhoA. Cellular location: Nucleus
products categories :
Cell Biology
products references :
Ashida, S., et al. Clin. Cancer Res. 12(9):2767-2773(2006). Fischer, J., et al. Biochem. Biophys. Res. Commun. 328(2):415-423(2005)
ncbi gi num :
7662284
ncbi acc num :
NP_055447.1
ncbi gb acc num :
NM_014632.3
uniprot acc num :
O94851
uniprot summary :
MICAL2: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Belongs to the Mical family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold; EC 1.14.13.-. Chromosomal Location of Human Ortholog: 11p15.3. Cellular Component: nucleus. Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; zinc ion binding; actin binding. Biological Process: actin filament depolymerization; heart development; cytoskeleton organization and biogenesis; heart looping; sulfur oxidation
size1 :
0.08 mL
price1 :
165 USD
size2 :
0.4 mL
price2 :
370
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
browse more products
questions and comments