catalog number :
MBS9212936
products full name :
TSPAN33 Antibody (C-term)
products short name :
[TSPAN33]
products name syn :
[Tetraspanin-33; Tspan-33; Penumbra; hPen; Proerythroblast new membrane; TSPAN33; PEN]
other names :
[tetraspanin-33; Tetraspanin-33; tetraspanin-33; tetraspanin 33; Penumbra; hPen; Proerythroblast new membrane]
products gene name :
[TSPAN33]
other gene names :
[TSPAN33; TSPAN33; PEN; PEN.; TSPAN-33; PEN; Tspan-33; hPen]
uniprot entry name :
TSN33_HUMAN
reactivity :
Human (Predicted Reactivity: Bovine, Mouse)
sequence positions :
[254-283]
specificity :
This TSPAN33 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 254-283 amino acids from the C-terminal region of human TSPAN33.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
app notes :
WB~~1:1000. IHC-P~~1:50~100. FC~~1:10~50
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Flow Cytometry (FC/FACS)
other info1 :
Clone Names: RB23231
other info2 :
Function: Plays an important role in normal erythropoiesis (By similarity). It has a role inthe differentiation of erythroid progenitors(By similarity). Regulates maturation and trafficking of the transmembranemetalloprotease ADAM10 (PubMed: 26686862 ). Negatively regulates ligand-induced Notch activityprobably by regulating ADAM10 activity (PubMed: 26686862 ). Cellular location: Cell membrane; Multi-pass membrane protein. Tissue location: Predominantly expressed in erythroblasts
products categories :
Cell Biology
products description :
TSPAN33 plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors.
products references :
Heikens, M.J., et al. Blood 109(8):3244-3252(2007). Huang, S., et al. Genomics 86(6):674-684(2005). Chen, Z., et al. Cancer Genet. Cytogenet. 162(2):95-98(2005)
ncbi acc num :
NP_848657.1
ncbi gb acc num :
NM_178562.4
uniprot summary :
TSPAN33: Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Belongs to the tetraspanin (TM4SF) family. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7q32.1. Cellular Component: cell surface; plasma membrane; integral to membrane. Molecular Function: enzyme binding. Biological Process: protein maturation