LPAR6 Antibody (Center) | MyBioSource MBS9212496 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LPAR6 Antibody (Center)

catalog :

MBS9212496

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes : Anti-LPAR6 Antibody (Center) at 1:2000 dilution . Lane 1: Molt-4 whole cell lysate . Lane 2: HepG2 whole cell lysate . Lane 3: Mouse heart tissue lysate . Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

image 2 :

All lanes : Anti-LPAR6 Antibody (Center) at 1:1000 dilution . Lane 1: Mouse heart tissue lysate . Lane 2: Rat heart tissue lysate . Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 39 kDa . Blocking/Dilution buffer: 5% NFDM/TBST.

image 3 :

LPAR6 Antibody (Center) (MBS9212496) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the LPAR6 antibody detected the LPAR6 protein (arrow).

product information

catalog number :

MBS9212496

products type :

Antibody

products full name :

LPAR6 Antibody (Center)

products short name :

[LPAR6]

products name syn :

[Lysophosphatidic acid receptor 6; LPA receptor 6; LPA-6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor; LPAR6; P2RY5]

other names :

[lysophosphatidic acid receptor 6; Lysophosphatidic acid receptor 6; lysophosphatidic acid receptor 6; lysophosphatidic acid receptor 6; Oleoyl-L-alpha-lysophosphatidic acid receptor; P2Y purinoceptor 5; P2Y5; Purinergic receptor 5; RB intron encoded G-protein coupled receptor]

products gene name :

[LPAR6]

other gene names :

[LPAR6; LPAR6; LAH3; P2Y5; ARWH1; HYPT8; P2RY5; P2RY5; LPA receptor 6; LPA-6; P2Y5]

uniprot entry name :

LPAR6_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence positions :

[106-134]

sequence length :

344

specificity :

This LPAR6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human LPAR6.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) - Paraffin, ELISA (EIA)

app notes :

WB~~1:1000. IHC-P~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Western Blot (WB)

image4 heading :

Immunohostochemistry (IHC)

image4 description :

LPAR6 Antibdy (Center) (MBS9212496) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of LPAR6 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

other info1 :

Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Cellular Location: Cell membrane; Multi-pass membrane protein. Tissue Location: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.

products categories :

Signal Transduction; GPCR Antibodies

products description :

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants.

products references :

Pasternack, S.M., et al. Arch. Dermatol. Res. 301(8):621-624(2009). Yanagida, K., et al. J. Biol. Chem. 284(26):17731-17741(2009). Tariq, M., et al. Br. J. Dermatol. 160(5):1006-1010(2009). Shimomura, Y., et al. J. Invest. Dermatol. 129(3):622-628(2009). Dereure, O. Ann Dermatol Venereol 135(11):794-795(2008)

ncbi gi num :

241982706

ncbi acc num :

NP_001155969.1

ncbi gb acc num :

NM_001162497.1

uniprot acc num :

P43657

ncbi mol weight :

39392

ncbi pathways :

Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161); Selenocompound Metabolism Pathway (10161)

ncbi summary :

uniprot summary :

P2RY5: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Defects in LPAR6 are the cause of woolly hair autosomal recessive type 1 with or without hypotrichosis (ARWH1). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Defects in LPAR6 are the cause of hypotrichosis type 8 (HYPT8). A condition characterized by the presence of less than the normal amount of hair. Affected individuals show progressive hair loss, thinning of scalp hair since early childhood, sparse body hair, and sparse eyebrows and eyelashes in some cases. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral. Chromosomal Location of Human Ortholog: 13q14. Cellular Component: plasma membrane; integral to membrane. Molecular Function: G-protein coupled receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway. Disease: Hypotrichosis 8

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage