MAFG Antibody (N-term) | MyBioSource MBS9212444 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MAFG Antibody (N-term)

catalog :

MBS9212444

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, chicken

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

MAFG Antibody (N-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the MAFG antibody detected the MAFG protein (arrow).

product information

catalog number :

MBS9212444

products type :

Antibody

products full name :

MAFG Antibody (N-term)

products short name :

[MAFG]

products name syn :

[Transcription factor MafG; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G; hMAF; MAFG]

other names :

[transcription factor MafG; Transcription factor MafG; transcription factor MafG; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G; V-maf musculoaponeurotic fibrosarcoma oncogene homolog G; hMAF]

products gene name :

[MAFG]

other gene names :

[MAFG; MAFG; hMAF]

uniprot entry name :

MAFG_HUMAN

clonality :

polyclonal

isotype :

Rabbit Ig

host :

rabbit

reactivity :

Human, mouse . Predicted: Bovine, Chicken

sequence positions :

[1-30]

sequence length :

162

specificity :

This MAFG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MAFG.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Calculated MW: 17850. Function: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:1115469.

products categories :

Cell Biology; Metabolism

products description :

Globin gene expression is regulated through nuclear factor. erythroid-2 (NFE2) elements located in enhancer-like locus control. regions positioned many kb upstream of alpha- and beta-gene. clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2. DNA-binding activity consists of a heterodimer containing a. ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM. 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like. superfamily of basic leucine zipper (bZIP) proteins (see MIM. 165160).

products references :

Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :. Berg, D.T., et al. J. Biol. Chem. 282(51):36837-36844(2007). Yamamoto, T., et al. Genes Cells 11(6):575-591(2006). Stelzl, U., et al. Cell 122(6):957-968(2005). Tramier, M., et al. Biophys. J. 83(6):3570-3577(2002)

ncbi gi num :

4505073

ncbi acc num :

NP_002350.1

ncbi gb acc num :

NM_002359.3

uniprot acc num :

O15525

ncbi pathways :

, Pathway (4097); , Pathway (4097)

ncbi summary :

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]

uniprot summary :

MAFG: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+). Belongs to the bZIP family. Maf subfamily. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 17q25.3. Cellular Component: nucleoplasm. Molecular Function: protein heterodimerization activity; sequence-specific DNA binding; transcription factor activity. Biological Process: regulation of cellular pH; regulation of transcription, DNA-dependent; transcription, DNA-dependent; in utero embryonic development; adult behavior; regulation of epidermal cell differentiation; blood coagulation; regulation of cell proliferation

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage