catalog number :
MBS9212388
products full name :
LBX1 Antibody (Center)
products short name :
[LBX1]
products name syn :
[Transcription factor LBX1; Ladybird homeobox protein homolog 1; LBX1; LBX1H]
other names :
[transcription factor LBX1; Transcription factor LBX1; transcription factor LBX1; ladybird homeobox 1; Ladybird homeobox protein homolog 1]
products gene name :
[LBX1]
other gene names :
[LBX1; LBX1; HPX6; HPX-6; LBX1H; homeobox; LBX1H]
uniprot entry name :
LBX1_HUMAN
reactivity :
Human, mouse (Predicted Reactivity: Rat, Xenopus)
sequence positions :
[127-155]
specificity :
This LBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the Central region of human LBX1.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
image1 heading :
Western Blot (WB)
other info2 :
Function: Transcription factor required for the development of GABAergic interneurons inthe dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord.
products categories :
Neuroscience; Signal Transduction
products description :
This gene and the orthologous mouse gene were found by. their homology to the Drosophila lady bird early and late homeobox. genes. In the mouse, this gene is a key regulator of muscle. precursor cell migration and is required for the acquisition of. dorsal identities of forelimb muscles.
products references :
Yu, M., et al. Genes Dev. 23(15):1737-1742(2009). Deloukas, P., et al. Nature 429(6990):375-381(2004). de Mollerat, X.J., et al. Hum. Mol. Genet. 12(16):1959-1971(2003). Kozmik, Z., et al. Genesis 29(4):172-179(2001). Jagla, K., et al. Mech. Dev. 53(3):345-356(1995)
ncbi acc num :
NP_006553.2
ncbi gb acc num :
NM_006562.4
ncbi summary :
This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]
uniprot summary :
LBX1: Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 10q24. Cellular Component: transcription factor complex; nucleus. Molecular Function: sequence-specific DNA binding; transcription factor activity. Biological Process: neuron fate determination; negative regulation of cell proliferation; muscle development; negative regulation of neuron differentiation; anatomical structure morphogenesis; transcription, DNA-dependent; heart looping; spinal cord motor neuron differentiation; regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification