BDK_1 Antibody (Center) | MyBioSource MBS9212035 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BDK_1 Antibody (Center)

catalog :

MBS9212035

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, flow cytometry, FACS, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of BDKRB1 Antibody (Center) in HepG2 cell line lysates (35ug/lane). BDKRB1 (arrow) was detected using the purified Pab.

image 2 :

BDKRB1 Antibody (Center) flow cytometric analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

product information

catalog number :

MBS9212035

products type :

Antibody

products full name :

BDK_1 Antibody (Center)

products short name :

[BDK_1]

products name syn :

[B1 bradykinin receptor, B1R, BK-1 receptor,BDKRB1, BRADYB1]

other names :

[B1 bradykinin receptor; B1 bradykinin receptor; B1 bradykinin receptor; bradykinin receptor B1]

products gene name :

[BDKRB1]

other gene names :

[BDKRB1; BDKRB1; B1R; BKR1; B1BKR; BKB1R; BDKRB2; BRADYB1; BRADYB1; B1R; BK-1 receptor]

uniprot entry name :

BKRB1_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[213-239]

sequence length :

353

specificity :

This BDK_1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-239 amino acids from the Central region of human BDK_1.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

app notes :

WB~~1:1000. FC~~1:10~50

image1 heading :

Western Blot (WB)

image2 heading :

Flow Cytometry (FC/FACS)

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN. Function: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Cellular Location: Cell membrane; Multi-pass membrane protein.

products categories :

Immunology; Metabolism; Signal Transduction; Phospho Antibodies

products description :

pathophysiologic conditions such asinflammation, trauma, burns, shock, and allergy.Two types of G-protein coupled receptors havebeen found which bind bradykinin and mediateresponses to these pathophysiologic conditions.BDKRB1 is one of these receptors and issynthesized de novo following tissue injury.Receptor binding leads to an increase in thecytosolic calcium ion concentration, ultimatelyresulting in chronic and acute inflammatoryresponses.

products references :

Bachvarov,D.R., et.al., Genomics 33 (3), 374-381 (1996)

ncbi gi num :

20544172

ncbi acc num :

NP_000701.2

ncbi gb acc num :

NM_000710.3

uniprot acc num :

P46663

ncbi mol weight :

40495

ncbi pathways :

Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623); Ribosome Pathway (623)

ncbi summary :

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

uniprot summary :

BKR1: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB1 sub-subfamily. Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR. Chromosomal Location of Human Ortholog: 14q32.1-q32.2. Cellular Component: neuron projection; endoplasmic reticulum; integral to plasma membrane; plasma membrane. Molecular Function: bradykinin receptor activity; protein binding; peptide binding. Biological Process: cell migration; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; response to mechanical stimulus; positive regulation of leukocyte migration; protein kinase C activation; response to lipopolysaccharide; negative regulation of cell growth; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of blood pressure; inflammatory response; sensory perception of pain

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage