product summary
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company name :
MyBioSource
product type :
antibody
product name :
PAPD5 Antibody (N-term)
catalog :
MBS9211826
quantity :
0.08 mL
price :
165 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
image
image 1 :
PAPD5 Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the PAPD5 Antibody detected the PAPD5 protein (arrow).
product information
catalog number :
MBS9211826
products type :
Antibody
products full name :
PAPD5 Antibody (N-term)
products short name :
[PAPD5]
products name syn :
[Non-canonical poly(A) RNA polymerase PAPD5; PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2; PAPD5]
other names :
[non-canonical poly(A) RNA polymerase PAPD5 isoform a; Non-canonical poly(A) RNA polymerase PAPD5; non-canonical poly(A) RNA polymerase PAPD5; PAP associated domain containing 5; PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; TUTase 3; Topoisomerase-related function protein 4-2; TRF4-2]
products gene name :
[PAPD5]
other gene names :
[PAPD5; PAPD5; TRF4-2; TUTase 3; TRF4-2]
uniprot entry name :
PAPD5_HUMAN
clonality :
Polyclonal
isotype :
Rabbit Ig
host :
Rabbit
reactivity :
Human
sequence positions :
[1-30]
sequence length :
698
specificity :
This PAPD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PAPD5.
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB~~1:1000
image1 heading :
Western Blot (WB)
other info2 :
Function: Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Cellular Location: Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Predominantly expressed in the cytoplasm (PubMed:18172165)
products description :
PAPD5 plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion.
products references :
Rose, J. Phd, et al. Mol. Med. (2010) In press :. Mullen, T.E., et al. Genes Dev. 22(1):50-65(2008). Walowsky, C., et al. J. Biol. Chem. 274(11):7302-7308(1999)
ncbi gi num :
256818780
ncbi acc num :
NP_001035374.2
ncbi gb acc num :
NM_001040284.2
uniprot acc num :
Q8NDF8
ncbi pathways :
Vitamin B6 Metabolism Pathway (64282); Vitamin B6 Metabolism Pathway (64282); Vitamin B6 Metabolism Pathway (64282); Vitamin B6 Metabolism Pathway (64282)
uniprot summary :
PAPD5: Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Belongs to the DNA polymerase type-B-like family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Transferase; EC 2.7.7.19; Nucleolus. Chromosomal Location of Human Ortholog: 16q12.1. Cellular Component: cytoplasm; nucleolus. Molecular Function: polynucleotide adenylyltransferase activity; DNA binding; metal ion binding; DNA-directed DNA polymerase activity. Biological Process: mitosis; cell division; mRNA processing; rRNA processing
size1 :
0.08 mL
price1 :
165 USD
size2 :
0.4 mL
price2 :
370
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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