Phospho-IRS2 (Y978) Antibody | MyBioSource MBS9211379 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Phospho-IRS2 (Y978) Antibody

catalog :

MBS9211379

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

ELISA, enzyme immunoassay, dot blot

more info or order :

MyBioSource product webpage

image

image 1 :

Dot blot analysis of anti-Phospho-IRS2-pY978 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

product information

catalog number :

MBS9211379

products type :

Antibody

products full name :

Phospho-IRS2 (Y978) Antibody

products short name :

[Phospho-IRS2 (Y978)]

products name syn :

[Insulin receptor substrate 2; IRS-2; IRS2]

other names :

[insulin receptor substrate 2; Insulin receptor substrate 2; insulin receptor substrate 2; insulin receptor substrate 2]

products gene name :

[IRS2]

other gene names :

[IRS2; IRS2; IRS-2; IRS-2]

uniprot entry name :

IRS2_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human (Predicted Reactivity: Mouse)

sequence length :

1338

specificity :

This IRS2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y978 of human IRS2.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Dot Blot (DB), ELISA (EIA)

app notes :

DB~~1:500

image1 heading :

Dot Blot (DB)

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN. Cellular Location: Cytoplasm, cytosol: Function: May mediate the control of various cellular.

products categories :

Cardiovascular; Metabolism; Signal Transduction; Phospho Antibodies

products description :

Insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. This protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

products references :

Hagg,D.A., Int. J. Mol. Med. 21 (6), 697-704 (2008). Platanias,L.C., J. Biol. Chem. 271 (1), 278-282 (1996). Sun,X.J., Nature 377 (6545), 173-177 (1995)

ncbi gi num :

38683860

ncbi acc num :

NP_003740.2

ncbi gb acc num :

NM_003749.2

uniprot acc num :

Q9Y4H2

ncbi mol weight :

137334

ncbi summary :

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

uniprot summary :

IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: plasma membrane; cytosol. Molecular Function: protein domain specific binding; protein binding; signal transducer activity; phosphoinositide 3-kinase binding; protein kinase binding; protein phosphatase binding; insulin receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; fibroblast growth factor receptor signaling pathway; regulation of lipid metabolic process; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; lipid homeostasis; positive regulation of insulin secretion; glucose metabolic process; signal transduction; positive regulation of fatty acid beta-oxidation; cell proliferation; positive regulation of glucose import; mammary gland development; cellular response to insulin stimulus; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; response to glucose stimulus; positive regulation of B cell proliferation; insulin receptor signaling pathway; innate immune response; brain development; negative regulation of B cell apoptosis; positive regulation of cell migration. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage