CYP4A11 (4A22) Antibody (C-term) | MyBioSource MBS9210357 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CYP4A11 (4A22) Antibody (C-term)

catalog :

MBS9210357

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of anti-CYP4A11 (4A22) Antibody (C-term) in NCI-H460 cell line lysates (35ug/lane).CYP4A11(arrow) was detected using the purified Pab.

image 2 :

Confocal immunofluorescent analysis of CYP4A11 (4A22) Antibody (C-term) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).

product information

catalog number :

MBS9210357

products type :

Antibody

products full name :

CYP4A11 (4A22) Antibody (C-term)

products short name :

[CYP4A11 (4A22)]

products name syn :

[Cytochrome P450 4A11; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; CYP4A11; CYP4A2]

other names :

[cytochrome P450 4A11; Cytochrome P450 4A11; cytochrome P450 4A11; cytochrome P450, family 4, subfamily A, polypeptide 11; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase (EC:1.14.15.3)]

products gene name :

[CYP4A11]

other gene names :

[CYP4A11; CYP4A11; CP4Y; CYP4A2; CYP4AII; CYP4A2; 20-HETE synthase]

uniprot entry name :

CP4AB_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[407-435]

sequence length :

519

specificity :

This CYP4A11 (4A22) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the C-terminal region of human CYP4A11 (4A22).

purity :

Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Immunohistochemistry - Parrafin (IHC-P), Westen Blot (WB), ELISA (EIA)

app notes :

IHC-P~~1:4000. WB~~1:1000

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescence (IF)

other info1 :

Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Tissue Location: Kidney and liver.

products categories :

Cancer; Cardiovascular; Metabolism; Signal Transduction

products description :

CYP4A11 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.

products references :

Sugimoto,K., Hypertension 52 (6), 1142-1148 (2008). Ward,N.C., Hypertension 51 (5), 1393-1398 (2008). Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

ncbi gi num :

158937242

ncbi acc num :

NP_000769.2

ncbi gb acc num :

NM_000778.3

uniprot acc num :

Q02928

ncbi mol weight :

59348

ncbi pathways :

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ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]

uniprot summary :

CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - fatty acid; Cofactor and Vitamin Metabolism - retinol; EC 1.14.15.3; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Oxidoreductase. Chromosomal Location of Human Ortholog: 1p33. Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm. Molecular Function: leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity. Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; renal water homeostasis; arachidonic acid metabolic process; leukotriene metabolic process; epoxygenase P450 pathway; sodium ion homeostasis; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; pressure natriuresis

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage