FABP4 Antibody (Y20) | MyBioSource MBS9210294 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

FABP4 Antibody (Y20)

catalog :

MBS9210294

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes : Anti-FABP4 Antibody (Y20) at 1:2000-1:8000 dilution. Lane 1: Human skeletal muslce lysate . Lane 2: Human lung lysate. Lane 3: Human heart lysate. Lane 4: Rat heart lysate . Lane 5: 3T3/L1 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 15 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

product information

catalog number :

MBS9210294

products type :

Antibody

products full name :

FABP4 Antibody (Y20)

products short name :

[FABP4]

products name syn :

[Fatty acid-binding protein; adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4; FABP4]

other names :

[fatty acid-binding protein, adipocyte; Fatty acid-binding protein, adipocyte; fatty acid-binding protein, adipocyte; fatty acid binding protein 4, adipocyte; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4]

products gene name :

[FABP4]

other gene names :

[FABP4; FABP4; aP2; ALBP; AFABP; A-FABP; HEL-S-104; ALBP; A-FABP; AFABP]

uniprot entry name :

FABP4_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Reactivity: Human, Mouse,Rat. Predicted: Rat, Pig, Bovine

sequence positions :

[1-30]

sequence length :

132

specificity :

This FABP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human FABP4.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

Vial Concentration: 0.47

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB~~1:2000-1:8000

image1 heading :

Test Data

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN. Function: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). Cellular Location: Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity)

products categories :

Cancer; Cardiovascular; Metabolism; Signal Transduction

products description :

FABP4 is a fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism.

products references :

Cabre,A., J. Lipid Res. 49 (8), 1746-1751 (2008). Fasshauer,M., Am. J. Hypertens. 21 (5), 582-586 (2008). Cabre,A., Clin. Chem. 54 (1), 181-187 (2008)

ncbi gi num :

4557579

ncbi acc num :

NP_001433.1

ncbi gb acc num :

NM_001442.2

uniprot acc num :

P15090

ncbi mol weight :

14719

ncbi summary :

FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]

uniprot summary :

FABP4: a lipid transport protein that is the predominant fatty acid binding protein found in adipocytes. Also expressed in macrophages. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Interacts with PPARG. Monomer. FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes. Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE. Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders. Belongs to the calycin superfamily,fatty-acid binding protein (FABP) family. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 8q21. Cellular Component: cytoplasm; lipid particle; nucleus. Molecular Function: transporter activity; fatty acid binding. Biological Process: cholesterol homeostasis; transport; triacylglycerol catabolic process; white fat cell differentiation; brown fat cell differentiation; cytokine production; negative regulation of protein kinase activity; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage