PRELP Antibody (Center) | MyBioSource MBS9210120 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PRELP Antibody (Center)

catalog :

MBS9210120

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

PRELP Antibody (Center) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the PRELP antibody detected PRELP protein (arrow).

image 2 :

PRELP Antibody (Center) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRELP Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

product information

catalog number :

MBS9210120

products type :

Antibody

products full name :

PRELP Antibody (Center)

products short name :

[PRELP]

products name syn :

[Prolargin; Proline-arginine-rich end leucine-rich repeat protein; PRELP; SLRR2A]

other names :

[prolargin; Prolargin; prolargin; proline/arginine-rich end leucine-rich repeat protein; Proline-arginine-rich end leucine-rich repeat protein]

products gene name :

[PRELP]

other gene names :

[PRELP; PRELP; MST161; SLRR2A; MSTP161; SLRR2A]

uniprot entry name :

PRELP_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[119-148]

sequence length :

382

specificity :

This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human PRELP.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

Vial Concentration: 0.5

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

app notes :

WB~~1:1000. IHC-P~~1:50~100

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Antigen Type: Synthetic Peptide. Function: May anchor basement membranes to the underlying connective tissue. Cellular Location: Secreted, extracellular space, extracellular matrix. Tissue Location: Connective tissue.

other info2 :

Antigen Source: HUMAN

products categories :

Developmental Biology; Signal Transduction

products description :

PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.

products references :

Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009). Grover, J., et al. Matrix Biol. 26(2):140-143(2007). Johnson, J.M., et al. Mol. Vis. 12, 1057-1066 (2006)

ncbi gi num :

4506041

ncbi acc num :

NP_002716.1

ncbi gb acc num :

NM_002725.3

uniprot acc num :

P51888

ncbi mol weight :

43810

ncbi pathways :

Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549); Cyanoamino Acid Metabolism Pathway (5549)

ncbi summary :

The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

uniprot summary :

PRELP: May anchor basement membranes to the underlying connective tissue. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular matrix; lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region; vesicle. Molecular Function: heparin binding; extracellular matrix structural constituent. Biological Process: keratan sulfate metabolic process; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; carbohydrate metabolic process; cell aging; pathogenesis; keratan sulfate catabolic process; skeletal development

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage