catalog number :
MBS9209523
products full name :
SPRR2A Antibody (C-term)
products short name :
[SPRR2A]
products name syn :
[Small proline-rich protein 2A; SPR-2A; 2-1; SPRR2A]
other names :
[small proline-rich protein 2A; Small proline-rich protein 2A; small proline-rich protein 2A; small proline-rich protein 2A; 2-1]
products gene name :
[SPRR2A]
other gene names :
[SPRR2A; SPRR2A; SPR-2A]
uniprot entry name :
SPR2A_HUMAN
sequence positions :
[48-72]
specificity :
This SPRR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-72 amino acids from the C-terminal region of human SPRR2A.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8° C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA)
image1 heading :
Western Blot (WB)
other info1 :
Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Cellular Location: Cytoplasm
products categories :
Cell Biology; Signal Transduction
products description :
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
products references :
Kainu, K., et al. Exp. Dermatol. 18(2):109-115(2009). Demetris, A.J., et al. J. Hepatol. 48(2):276-288(2008). Tong, L., et al. Invest. Ophthalmol. Vis. Sci. 47(5):1938-1946(2006). Hong, S.H., et al. Mol. Cells 17(3):477-484(2004). Cabral, A., et al. J. Biol. Chem. 278(20):17792-17799(2003)
ncbi acc num :
NP_005979.1
ncbi gb acc num :
NM_005988.2
uniprot summary :
SPRR2A: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Belongs to the cornifin (SPRR) family. During squamous differentiation of epidermal keratinocytes. Chromosomal Location of Human Ortholog: 1q21-q22. Cellular Component: cytoplasm; cornified envelope. Molecular Function: protein binding. Biological Process: keratinocyte differentiation; epidermis development; keratinization