ANO6 Antibody (N-term) | MyBioSource MBS9208932 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ANO6 Antibody (N-term)

catalog :

MBS9208932

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

ANO6 Antibody (N-term) western blot analysis in SW480 cell line lysates (35ug/lane).This demonstrates the ANO6 antibody detected the ANO6 protein (arrow).

product information

catalog number :

MBS9208932

products type :

Antibody

products full name :

ANO6 Antibody (N-term)

products short name :

[ANO6]

products name syn :

[Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, SCAN channel, Transmembrane protein 16F, ANO6, TMEM16F]

other names :

[anoctamin-6 isoform a; Anoctamin-6; anoctamin-6; anoctamin 6; Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F]

products gene name :

[ANO6]

other gene names :

[ANO6; ANO6; SCTS; BDPLT7; TMEM16F; TMEM16F; SCAN channel]

uniprot entry name :

ANO6_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[68-96]

sequence length :

929

specificity :

This ANO6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human ANO6.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

Vial Concentration: 0.5

storage stability :

Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Antigen Type: Synthetic Peptide. Crown Antibody: Yes

other info2 :

Antigen Source: HUMAN. Function: Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. Cellular Location: Cell membrane; Multi-pass membrane protein Note=Shows an intracellular localization according to PubMed:22075693. Tissue Location: Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer

products categories :

Crown Antibodies

products description :

May act as a calcium-activated chloride channel.

products references :

Rose, J. Phd, et al. Mol. Med. (2010) In press :. Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009) :. Katoh, M., et al. Int. J. Oncol. 24(5):1345-1349(2004). Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :

ncbi gi num :

218156299

ncbi acc num :

NP_001020527.2

ncbi gb acc num :

NM_001025356.2

uniprot acc num :

Q4KMQ2

ncbi mol weight :

106165

ncbi pathways :

Streptomycin Biosynthesis Pathway (196527); Streptomycin Biosynthesis Pathway (196527); Streptomycin Biosynthesis Pathway (196527)

ncbi summary :

This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

uniprot summary :

ANO6: May act as a calcium-activated chloride channel. It is essential for calcium-dependent exposure of phosphatidylserine on the surface of activated platelets, a process necessary to trigger the clotting system. Defects in ANO6 are the cause of Scott syndrome (SCTS). A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. Belongs to the anoctamin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, ion channel; Transporter; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 12q12. Cellular Component: cell surface; membrane; plasma membrane; intracellular. Molecular Function: phospholipid scramblase activity; protein homodimerization activity; intracellular calcium activated chloride channel activity; voltage-gated ion channel activity; voltage-gated chloride channel activity; calcium activated cation channel activity. Biological Process: activation of blood coagulation via clotting cascade; dendritic cell chemotaxis; chloride transport; phospholipid scrambling; blood coagulation; lipid transport; transmembrane transport; cation transport. Disease: Scott Syndrome

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage