MLXIPL Antibody (C-term) | MyBioSource MBS9208417 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MLXIPL Antibody (C-term)

catalog :

MBS9208417

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilution . Lane 1: Neuro-2a whole cell lysate . Lane 2: SW620 whole cell lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 93 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.

image 2 :

All lanes : Anti-MLXIPL Antibody (C-term) at 1:2000 dilution . Lane 1: K562 whole cell lysate . Lane 2: NCI-H1299 whole cell lysate . Lane 3: Neuro-2a whole cell lysate . Lane 4: SW620 whole cell lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 93 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

image 3 :

MLXIPL Antibody (C-term) (Cat. #MBS9208417) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the MLXIPL antibody detected the MLXIPL protein (arrow).

product information

catalog number :

MBS9208417

products type :

Antibody

products full name :

MLXIPL Antibody (C-term)

products short name :

[MLXIPL]

products name syn :

[Carbohydrate-responsive element-binding protein; ChREBP; Class D basic helix-loop-helix protein 14; bHLHd14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Williams-Beuren syndrome chromosomal region 14 protein; MLXIPL; BHLHD14; MIO; WBSCR14]

other names :

[carbohydrate-responsive element-binding protein isoform alpha; Carbohydrate-responsive element-binding protein; carbohydrate-responsive element-binding protein; MLX interacting protein-like; Class D basic helix-loop-helix protein 14; bHLHd14; MLX interactor; MLX-interacting protein-like; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Williams-Beuren syndrome chromosomal region 14 protein]

products gene name :

[MLXIPL]

other gene names :

[MLXIPL; MLXIPL; MIO; CHREBP; MONDOB; WBSCR14; WS-bHLH; bHLHd14; BHLHD14; MIO; WBSCR14; ChREBP; bHLHd14; WS-bHLH]

uniprot entry name :

MLXPL_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human, Mouse

sequence positions :

[624-653]

sequence length :

722

specificity :

This MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the C-terminal region of human MLXIPL.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

concentration :

Vial Concentration: 0.32

storage stability :

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot

image3 heading :

Western Blot

image4 heading :

Immunohistochemistry

image4 description :

MLXIPL Antibody (C-term) (Cat. #MBS9208417)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MLXIPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

other info1 :

Antigen Type: Synthetic Peptide

other info2 :

Antigen Source: HUMAN. Function: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). Cellular Location: Nucleus. Tissue Location: Expressed in liver, heart, kidney, cerebellum and intestinal tissues

products categories :

Cancer; Cardiovascular; Metabolism

products description :

This gene encodes a basic helix-loop-helix leucine zipper. transcription factor of the Myc/Max/Mad superfamily. This protein. forms a heterodimeric complex and binds and activates, in a. glucose-dependent manner, carbohydrate response element (ChoRE). motifs in the promoters of triglyceride synthesis genes. The gene. is deleted in Williams-Beuren syndrome, a multisystem developmental. disorder caused by the deletion of contiguous genes at chromosome. 7q11.23.

products references :

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010). Johansen, C.T., et al. Nat. Genet. 42(8):684-687(2010). Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010). Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :. Reynolds, C.A., et al. Hum. Mol. Genet. 19(10):2068-2078(2010)

ncbi gi num :

14602433

ncbi acc num :

NP_116569.1

ncbi gb acc num :

NM_032951.2

uniprot acc num :

Q9NP71

ncbi mol weight :

93073

ncbi summary :

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008]

uniprot summary :

ChREBP: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5 -CACGTG-3 . Binds DNA as a heterodimer with TCFL4/MLX. Expressed in liver, heart, kidney, cerebellum and intestinal tissues. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus. Molecular Function: protein homodimerization activity; DNA binding; protein heterodimerization activity; transcription factor binding; transcription factor activity. Biological Process: positive regulation of fatty acid biosynthetic process; anatomical structure morphogenesis; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of peptidyl-serine phosphorylation; positive regulation of cellular metabolic process; positive regulation of lipid biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; glucose mediated signaling; regulation of transcription from RNA polymerase II promoter; regulation of fatty acid biosynthetic process; regulation of transcription, DNA-dependent; fatty acid homeostasis; positive regulation of cell proliferation; positive regulation of glycolysis; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent. Disease: Williams-beuren Syndrome

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage