SLAMF6 Antibody (C-term) | MyBioSource MBS9208379 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SLAMF6 Antibody (C-term)

catalog :

MBS9208379

quantity :

0.08 mL

price :

165 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

SLAMF6 Antibody (C-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the SLAMF6 antibody detected the SLAMF6 protein (arrow).

product information

catalog number :

MBS9208379

products type :

Antibody

products full name :

SLAMF6 Antibody (C-term)

products short name :

[SLAMF6]

products name syn :

[SLAM family member 6; Activating NK receptor; NK-T-B-antigen; NTB-A; CD352; SLAMF6; KALI]

other names :

[SLAM family member 6 isoform 1; SLAM family member 6; SLAM family member 6; SLAM family member 6; Activating NK receptor; NK-T-B-antigen; NTB-A; CD_antigen: CD352]

products gene name :

[SLAMF6]

other gene names :

[SLAMF6; SLAMF6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; KALI; NTB-A]

uniprot entry name :

SLAF6_HUMAN

clonality :

Polyclonal

isotype :

Rabbit Ig

host :

Rabbit

reactivity :

Human

sequence positions :

[277-305]

specificity :

This SLAMF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 amino acids from the C-terminal region of human SLAMF6.

purity :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

form :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

storage stability :

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB~~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed: 11489943 , PubMed: 16920955 ).Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed: 16920955 ). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed: 22184727 , PubMed: 16920955 ). Promotes recruitment of RORC to the IL-17 promoter (PubMed: 22989874 ). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity).

other info2 :

Cellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Location: Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes (PubMed:11489943) Increased surface expression on T-cells of systemic lupus erythematosus (SLE) patients (PubMed:22184727)

products categories :

Immunology

products description :

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

products references :

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :. Davila, S., et al. Genes Immun. 11(3):232-238(2010). Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

ncbi gi num :

296040491

ncbi acc num :

NP_001171643.1

ncbi gb acc num :

NM_001184714.1

uniprot acc num :

Q96DU3

ncbi mol weight :

37345

ncbi summary :

uniprot summary :

SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q23.2. Cellular Component: plasma membrane; integral to membrane. Molecular Function: receptor activity

size1 :

0.08 mL

price1 :

165 USD

size2 :

0.4 mL

price2 :

370

more info or order :

MyBioSource product webpage