catalog number :
MBS9208301
products full name :
TGOLN2 Antibody (C-term)
products short name :
[TGOLN2]
products name syn :
[Trans-Golgi network integral membrane protein 2; TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51; TGOLN2; TGN46; TGN51]
other names :
[trans-Golgi network integral membrane protein 2 isoform 2; Trans-Golgi network integral membrane protein 2; trans-Golgi network integral membrane protein 2; trans-golgi network protein 2; TGN38 homolog; TGN46; TGN48; Trans-Golgi network protein TGN51]
products gene name :
[TGOLN2]
other gene names :
[TGOLN2; TGOLN2; TGN38; TGN46; TGN48; TGN51; TTGN2; TGN46; TGN51]
uniprot entry name :
TGON2_HUMAN
reactivity :
Human. Predicted: Mouse.
sequence positions :
[399-427]
specificity :
This TGOLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the C-terminal region of human TGOLN2.
purity :
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
form :
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
storage stability :
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
tested application :
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
app notes :
WB~~1:1000. FC~~1:10~50
image1 heading :
Western Blot (WB)
image2 heading :
Flow Cytometry (FC/FACS)
other info1 :
Function: May be involved in regulating membranetraffic to and from trans-Golgi network. Cellular Location: Cell membrane; Single-pass type I membraneprotein. Golgi apparatus, trans-Golgi networkmembrane; Single- pass type I membraneprotein. Note=Primarily in trans-Golginetwork. Cycles between the trans-Golginetwork and the cell surface returning viaendosomes. Tissue Location: Isoform TGN46 is widely expressed. IsoformTGN51 is more abundant in fetal lung andkidney. Isoform TGN48 is barely expressed inembryonic kidney and promyelocytic cells.
products description :
TGOLN2 may be involved in regulating membrane traffic to and from trans-Golgi network.
products references :
Wu,C., et.al., Proteomics 7 (11), 1775-1785 (2007). Honing,S., et.al., Mol. Cell 18 (5), 519-531 (2005)
ncbi acc num :
NP_001193769.1
ncbi gb acc num :
NM_001206840.1
ncbi summary :
This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
uniprot summary :
TGOLN2: May be involved in regulating membrane traffic to and from trans-Golgi network. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 2p11.2. Cellular Component: nucleoplasm; Golgi apparatus; transport vesicle; plasma membrane; integral to membrane; trans-Golgi network. Molecular Function: protein binding